A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer's disease

被引:10
|
作者
Faridar, Alireza [1 ]
Eid, Abdulmunaim M. [1 ]
Thome, Aaron D. [1 ]
Zhao, Weihua [1 ]
Beers, David R. [1 ]
Pascual, Maria B. [1 ]
Nakawah, Mohammad O. [1 ]
Roman, Gustavo C. [1 ]
Davis, Charles S. [2 ]
Grundman, Michael [3 ,4 ]
Masdeu, Joseph C. [1 ]
Appel, Stanley H. [1 ]
机构
[1] Houston Methodist Res Inst, Stanley H Appel Dept Neurol, 6565 Fannin St,Suite P3-201, Houston, TX 77030 USA
[2] CSD Biostat Inc, Oro Valley, AZ USA
[3] Global R&D Partners LLC, San Diego, CA USA
[4] Univ Calif San Diego, San Diego, CA USA
关键词
D O I
10.1186/s40035-023-00387-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Trial registrationClinicalTrials.gov Identifier: NCT05821153, Registered April 20 2023, Retrospectively registered, https://classic.clinicaltrials.gov/ct2/show/NCT05821153
引用
收藏
页数:4
相关论文
共 50 条
  • [21] An open-label pilot study of transdermal selegiline for depression in Parkinson's disease patients
    Abhishek, R.
    Eng, M.
    Lyons, K. E.
    Pahwa, R.
    MOVEMENT DISORDERS, 2008, 23 (01) : S304 - S305
  • [22] Adjunctive low-dose docosahexaenoic acid (DHA) for major depression: An open-label pilot trial
    Smith, Deidre J.
    Sarris, Jerome
    Dowling, Nathan
    O'Connor, Manjula
    Ng, Chee H.
    NUTRITIONAL NEUROSCIENCE, 2018, 21 (03) : 224 - 228
  • [23] An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients
    Knopman, D
    Patterson, M
    ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2001, 15 (03): : 162 - 165
  • [24] Low dose oral ketamine treatment in chronic suicidality: An open-label pilot study
    Adem T. Can
    Daniel F. Hermens
    Megan Dutton
    Cyrana C. Gallay
    Emma Jensen
    Monique Jones
    Jennifer Scherman
    Denise A. Beaudequin
    Cian Yang
    Paul E. Schwenn
    Jim Lagopoulos
    Translational Psychiatry, 11
  • [25] Low dose oral ketamine treatment in chronic suicidality: An open-label pilot study
    Can, Adem T.
    Hermens, Daniel F.
    Dutton, Megan
    Gallay, Cyrana C.
    Jensen, Emma
    Jones, Monique
    Scherman, Jennifer
    Beaudequin, Denise A.
    Yang, Cian
    Schwenn, Paul E.
    Lagopoulos, Jim
    TRANSLATIONAL PSYCHIATRY, 2021, 11 (01)
  • [26] Inhaled Low-Dose Iloprost for Pulmonary Hypertension: A Prospective, Multicenter, Open-Label Study
    Sun, Yun-Juan
    Xiong, Chang-Ming
    Shan, Guang-Liang
    Gu, Qing
    Zeng, Wei-Jie
    Lu, Xian-Ling
    Zhu, Feng
    Liu, Zhi-Hong
    Ni, Xin-Hai
    He, Jian-Guo
    CLINICAL CARDIOLOGY, 2012, 35 (06) : 365 - 370
  • [27] Low-Dose Divalproex in Agitated Patients with Alzheimer's Disease
    Dolder, Christian
    McKinsey, Jonathan
    JOURNAL OF PSYCHIATRIC PRACTICE, 2010, 16 (01) : 63 - 67
  • [28] Open-label, multicenter, phase 3 extension study of the safety and efficacy of donepezil in patients with Alzheimer disease
    Doody, RS
    Geldmacher, DS
    Gordon, B
    Perdomo, CA
    Pratt, RD
    ARCHIVES OF NEUROLOGY, 2001, 58 (03) : 427 - 433
  • [29] An open-label study on adding rotigotine treatment to low dose of pramipexole or ropinirole in patients with advanced Parkinson's disease
    Kim, J. M.
    Chung, S. J.
    Kim, J. W.
    Thierfelder, S.
    Bauer, L.
    Jeon, B. S.
    MOVEMENT DISORDERS, 2013, 28 : S220 - S220
  • [30] Effect of tacrine on behavioral symptoms in Alzheimer's disease: An open-label study
    Kaufer, DI
    Cummings, JL
    Christine, D
    JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, 1996, 9 (01) : 1 - 6