High Throughput Microfluidics Platform to Assess Synthetic Lethality and Novel Therapeutic Drug Combinations

被引:0
|
作者
Soltis, Anthony [1 ]
Zhelyazkova, Boryana [1 ]
Drane, Pascal [1 ]
Eleftheriadis, Efstathios [1 ]
Ventresco, Andrew [1 ]
Weitz, David [2 ]
Iafrate, Anthony John [3 ]
Lee, Arlinda [4 ]
机构
[1] Hunter Biodiscovery, Boston, MA USA
[2] Harvard Univ, Cambridge, MA 02138 USA
[3] Massachusetts Gen Hosp, Boston, MA 02114 USA
[4] Hunter Biodiscovery, New York, NY USA
关键词
D O I
10.1182/blood-2023-190651
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:3
相关论文
共 50 条
  • [41] High-Throughput Purification Platform in Support of Drug Discovery
    Liu, Min
    Chen, Kuanchang
    Christian, Denny
    Fatima, Tazeen
    Pissamitski, Natalya
    Streckfuss, Eric
    Zhang, Chaowei
    Xia, Lei
    Borges, Scott
    Shi, Zhicai
    Vachal, Petr
    Tata, James
    Athanasopoulos, John
    ACS COMBINATORIAL SCIENCE, 2012, 14 (01) : 51 - 59
  • [42] High-throughput kinase profiling as a platform for drug discovery
    Goldstein, David M.
    Gray, Nathanael S.
    Zarrinkar, Patrick P.
    NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (05) : 391 - 397
  • [43] Droplet-Based Microfluidics Platform for Ultra-High-Throughput Bioprospecting of Cellulolytic Microorganisms
    Najah, Majdi
    Calbrix, Raphael
    Mahendra-Wijaya, I. Putu
    Beneyton, Thomas
    Griffiths, Andrew D.
    Drevelle, Antoine
    CHEMISTRY & BIOLOGY, 2014, 21 (12): : 1722 - 1732
  • [44] Novel platform for automation of high throughput drug discovery using patient derived colorectal cancer organoids
    Lim, Angeline
    Tong, Zhisong
    Macha, Prathyushakrishna
    Sirenkp, Oksana
    CANCER RESEARCH, 2023, 83 (07)
  • [45] Novel patient derived colorectal cancer organoid platform for automated high throughput drug discovery applications
    Lim, A.
    Tong, Z.
    Fraser, E.
    Durban, V.
    Macha, P.
    Buddhikot, O.
    Baranowski, T.
    Baade, J.
    Katiyar, A.
    Amijee, H.
    Sirenko, O.
    MOLECULAR BIOLOGY OF THE CELL, 2023, 34 (02) : 139 - 140
  • [46] The use of conditionally reprogrammed cells for high throughput screening for novel drug combinations to treat drug resistant triple negative breast cancers
    Aguilar-Mahecha, Adriana
    Chabot, Catherine
    Santos-Martinez, Nancy
    Darini, Cedric
    Hajira, Midhet
    Kong, Tim
    Morin, Genevieve
    Huang, Sidong
    Park, Morag
    Basik, Mark
    CANCER RESEARCH, 2020, 80 (16)
  • [47] Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM
    Kim, Yong-Wan
    Liu, Ta Jen
    Koul, Dimpy
    Tiao, Ningyi
    Feroze, Abdullah H.
    Wang, Jing
    Powis, Garth
    Yung, W. K. Alfred
    NEURO-ONCOLOGY, 2011, 13 (04) : 367 - 375
  • [48] Novel therapeutic agents in the development of effective drug combinations to treat glioma
    Avdieiev, S.
    Gera, L.
    Hodges, R.
    FEBS JOURNAL, 2016, 283 : 380 - 380
  • [49] A Novel Synthetic Tumor Platform for Screening Drug Delivery systems
    Tang, Yuan
    Soroush, Fariborz
    Deosarkar, Sudhir
    Wang, Bin
    Pandian, Prabhakar
    Kiani, Mohammad F.
    FASEB JOURNAL, 2016, 30
  • [50] Mining high-throughput screens for cancer drug targets-lessons from yeast chemical-genomic profiling and synthetic lethality
    Heiskanen, Marja A.
    Aittokallio, Tero
    WILEY INTERDISCIPLINARY REVIEWS-DATA MINING AND KNOWLEDGE DISCOVERY, 2012, 2 (03) : 263 - 272