Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models (vol 41, pg 399, 2023)

被引：0

作者：

Allesoe, Rosa Lundbye ^{[1
]}

Lundgaard, Agnete Troen ^{[1
]}

Hernandez Medina, Ricardo ^{[1
]}

Aguayo-Orozco, Alejandro ^{[1
]}

Johansen, Joachim ^{[1
]}

Nissen, Jakob Nybo ^{[1
]}

Brorsson, Caroline ^{[1
]}

Mazzoni, Gianluca ^{[1
]}

Niu, Lili ^{[1
]}

Biel, Jorge Hernansanz ^{[1
]}

Leal Rodriguez, Cristina ^{[1
]}

Brasas, Valentas ^{[1
]}

Webel, Henry ^{[1
]}

Benros, Michael Eriksen ^{[1
]}

Pedersen, Anders Gorm ^{[1
]}

Chmura, Piotr Jaroslaw ^{[1
]}

Jacobsen, Ulrik Plesner ^{[1
]}

Mari, Andrea ^{[1
]}

Koivula, Robert ^{[1
]}

Mahajan, Anubha ^{[1
]}

Vinuela, Ana ^{[1
]}

Tajes, Juan Fernandez ^{[1
]}

Sharma, Sapna ^{[1
]}

Haid, Mark ^{[1
]}

Hong, Mun-Gwan B. ^{[1
]}

Musholt, Petra ^{[1
]}

De Masi, Federico ^{[1
]}

Vogt, Josef ^{[1
]}

Pedersen, Helle Krogh ^{[1
]}

Gudmundsdottir, Valborg ^{[1
]}

Jones, Angus ^{[1
]}

Kennedy, Gwen ^{[1
]}

Bell, Jimmy ^{[1
]}

Thomas, E. Louise ^{[1
]}

Frost, Gary ^{[1
]}

Thomsen, Henrik ^{[1
]}

Hansen, Elizaveta ^{[1
]}

Hansen, Tue Haldor ^{[1
]}

Vestergaard, Henrik ^{[1
]}

Muilwijk, Mirthe T. ^{[1
]}

Blom, Marieke M. ^{[1
]}

't Hart, Leen ^{[1
]}

Pattou, Francois ^{[1
]}

Raverdy, Violeta ^{[1
]}

Brage, Soren ^{[1
]}

Kokkola, Tarja ^{[1
]}

Heggie, Alison ^{[1
]}

McEvoy, Donna ^{[1
]}

Mourby, Miranda ^{[1
]}

Kaye, Jane ^{[1
]}

机构：

[1] Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Prot Res, Copenhagen, Denmark

来源：

NATURE BIOTECHNOLOGY | 2023年 / 41卷 / 07期

关键词：

D O I：

10.1038/s41587-023-01805-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

引用

页码：1026 / 1026

页数：1

共 11 条

[1] Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models
Allesoe, Rosa Lundbye
Lundgaard, Agnete Troen
Medina, Ricardo Hernandez
Aguayo-Orozco, Alejandro
Johansen, Joachim
Nissen, Jakob Nybo
Brorsson, Caroline
Mazzoni, Gianluca
Niu, Lili
Biel, Jorge Hernansanz
Brasas, Valentas
Webel, Henry
Benros, Michael Eriksen
Pedersen, Anders Gorm
Chmura, Piotr Jaroslaw
Jacobsen, Ulrik Plesner
Mari, Andrea
Koivula, Robert
Mahajan, Anubha
Vinuela, Ana
Tajes, Juan Fernandez
Sharma, Sapna
Haid, Mark
Hong, Mun-Gwan
Musholt, Petra B.
De Masi, Federico
Vogt, Josef
Pedersen, Helle Krogh
Gudmundsdottir, Valborg
Jones, Angus
Kennedy, Gwen
Bell, Jimmy
Thomas, E. Louise
Frost, Gary
Thomsen, Henrik
Hansen, Elizaveta
Hansen, Tue Haldor
Vestergaard, Henrik
Muilwijk, Mirthe
Blom, Marieke T.
Hart, Leen M. T.
Pattou, Francois
Raverdy, Violeta
Brage, Soren
Kokkola, Tarja
Heggie, Alison
McEvoy, Donna
Mourby, Miranda
Kaye, Jane
Hattersley, Andrew
NATURE BIOTECHNOLOGY, 2023, 41 (03) : 399 - +
[2] Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models
Rosa Lundbye Allesøe
Agnete Troen Lundgaard
Ricardo Hernández Medina
Alejandro Aguayo-Orozco
Joachim Johansen
Jakob Nybo Nissen
Caroline Brorsson
Gianluca Mazzoni
Lili Niu
Jorge Hernansanz Biel
Cristina Leal Rodríguez
Valentas Brasas
Henry Webel
Michael Eriksen Benros
Anders Gorm Pedersen
Piotr Jaroslaw Chmura
Ulrik Plesner Jacobsen
Andrea Mari
Robert Koivula
Anubha Mahajan
Ana Vinuela
Juan Fernandez Tajes
Sapna Sharma
Mark Haid
Mun-Gwan Hong
Petra B. Musholt
Federico De Masi
Josef Vogt
Helle Krogh Pedersen
Valborg Gudmundsdottir
Angus Jones
Gwen Kennedy
Jimmy Bell
E. Louise Thomas
Gary Frost
Henrik Thomsen
Elizaveta Hansen
Tue Haldor Hansen
Henrik Vestergaard
Mirthe Muilwijk
Marieke T. Blom
Leen M. ‘t Hart
Francois Pattou
Violeta Raverdy
Soren Brage
Tarja Kokkola
Alison Heggie
Donna McEvoy
Miranda Mourby
Jane Kaye
Nature Biotechnology, 2023, 41 : 399 - 408
[3] Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models
Rosa Lundbye Allesøe
Agnete Troen Lundgaard
Ricardo Hernández Medina
Alejandro Aguayo-Orozco
Joachim Johansen
Jakob Nybo Nissen
Caroline Brorsson
Gianluca Mazzoni
Lili Niu
Jorge Hernansanz Biel
Cristina Leal Rodríguez
Valentas Brasas
Henry Webel
Michael Eriksen Benros
Anders Gorm Pedersen
Piotr Jaroslaw Chmura
Ulrik Plesner Jacobsen
Andrea Mari
Robert Koivula
Anubha Mahajan
Ana Vinuela
Juan Fernandez Tajes
Sapna Sharma
Mark Haid
Mun-Gwan Hong
Petra B. Musholt
Federico De Masi
Josef Vogt
Helle Krogh Pedersen
Valborg Gudmundsdottir
Angus Jones
Gwen Kennedy
Jimmy Bell
E. Louise Thomas
Gary Frost
Henrik Thomsen
Elizaveta Hansen
Tue Haldor Hansen
Henrik Vestergaard
Mirthe Muilwijk
Marieke T. Blom
Leen M. ‘t Hart
Francois Pattou
Violeta Raverdy
Soren Brage
Tarja Kokkola
Alison Heggie
Donna McEvoy
Miranda Mourby
Jane Kaye
Nature Biotechnology, 2023, 41 : 1026 - 1026
[4] Systems Approach to Pathogenic Mechanism of Type 2 Diabetes and Drug Discovery Design Based on Deep Learning and Drug Design Specifications
Chang, Shen
Chen, Jian-You
Chuang, Yung-Jen
Chen, Bor-Sen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (01) : 1 - 39
[5] Deep-learning models for the detection and incidence prediction of chronic kidney disease and type 2 diabetes from retinal fundus images
Zhang, Kang
Liu, Xiaohong
Xu, Jie
Yuan, Jin
Cai, Wenjia
Chen, Ting
Wang, Kai
Gao, Yuanxu
Nie, Sheng
Xu, Xiaodong
Qin, Xiaoqi
Su, Yuandong
Xu, Wenqin
Olvera, Andrea
Xue, Kanmin
Li, Zhihuan
Zhang, Meixia
Zeng, Xiaoxi
Zhang, Charlotte L.
Li, Oulan
Zhang, Edward E.
Zhu, Jie
Xu, Yiming
Kermany, Daniel
Zhou, Kaixin
Pan, Ying
Li, Shaoyun
Lai, Iat Fan
Chi, Ying
Wang, Changuang
Pei, Michelle
Zang, Guangxi
Zhang, Qi
Lau, Johnson
Lam, Dennis
Zou, Xiaoguang
Wumaier, Aizezi
Wang, Jianquan
Shen, Yin
Hou, Fan Fan
Zhang, Ping
Xu, Tao
Zhou, Yong
Wang, Guangyu
NATURE BIOMEDICAL ENGINEERING, 2021, 5 (06) : 533 - +
[6] Deep-learning models for the detection and incidence prediction of chronic kidney disease and type 2 diabetes from retinal fundus images
Kang Zhang
Xiaohong Liu
Jie Xu
Jin Yuan
Wenjia Cai
Ting Chen
Kai Wang
Yuanxu Gao
Sheng Nie
Xiaodong Xu
Xiaoqi Qin
Yuandong Su
Wenqin Xu
Andrea Olvera
Kanmin Xue
Zhihuan Li
Meixia Zhang
Xiaoxi Zeng
Charlotte L. Zhang
Oulan Li
Edward E. Zhang
Jie Zhu
Yiming Xu
Daniel Kermany
Kaixin Zhou
Ying Pan
Shaoyun Li
Iat Fan Lai
Ying Chi
Changuang Wang
Michelle Pei
Guangxi Zang
Qi Zhang
Johnson Lau
Dennis Lam
Xiaoguang Zou
Aizezi Wumaier
Jianquan Wang
Yin Shen
Fan Fan Hou
Ping Zhang
Tao Xu
Yong Zhou
Guangyu Wang
Nature Biomedical Engineering, 2021, 5 : 533 - 545
[7] Opportunistic detection of type 2 diabetes using deep learning from frontal chest radiographs ( vol 15, pg 4817, 2024 )
Pyrros, Ayis
Borstelmann, Stephen M.
Mantravadi, Ramana
Zaiman, Zachary
Thomas, Kaesha
Price, Brandon
Greenstein, Eugene
Siddiqui, Nasir
Willis, Melinda
Shulhan, Ihar
Hines-Shah, John
Horowitz, Jeanne M.
Nikolaidis, Paul
Lungren, Matthew P.
Rodriguez-Fernandez, Jorge Mario
Gichoya, Judy Wawira
Koyejo, Sanmi
Flanders, Adam E.
Khandwala, Nishith
Gupta, Amit
Garrett, John W.
Cohen, Joseph Paul
Layden, Brian T.
Pickhardt, Perry J.
Galanter, William
NATURE COMMUNICATIONS, 2024, 15 (01)
[8] Therapeutic targets to reduce cardiovascular disease in type 2 diabetes (Reprinted from Nature Reviews Drug Discovery, vol 8, pg 361-367, 2009)
DeSouza, Cyrus
Fonseca, Vivian
NATURE REVIEWS DRUG DISCOVERY, 2010, : 5 - 11
[9] Immunomodulatory Functions of Adipose Mesenchymal Stromal/Stem Cell Derived From Donors With Type 2 Diabetes and Obesity on CD4 T Cells (vol 41, pg 505,2023)
Mahmoud, Marwa
Juntunen, Miia
Adnan, Amna
Kummola, Laura
Junttila, Ilkka S.
Kelloniemi, Minna
Tyrvainen, Tuula
Huhtala, Heini
Abd El Fattah, Abeer, I
Amr, Khalda
El Erian, Alaa Mohamad
Patrikoski, Mimmi
Miettinen, Susanna
STEM CELLS, 2023, 42 (12) : 1101 - 1101
[10] A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase by chalcone derivatives (vol 10, pg 5510, 2019)
Rocha, Sonia
Sousa, Adelaide
Ribeiro, Daniela
Correia, Catarina M.
Silva, Vera L. M.
Santos, Clementina M. M.
Silva, Artur M. S.
Araujo, Alberto N.
Fernandes, Eduarda
Freitas, Marisa
FOOD & FUNCTION, 2019, 10 (09) : 6203 - 6203

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