Neurotoxins and pore forming toxins in sea anemones: Potential candidates for new drug development

被引:4
|
作者
Wang, Zhi-Lin [1 ]
Zhang, Shu-Yi [1 ]
Hao, Shuang-Li [1 ,2 ]
Yang, Wan -Xi [1 ,2 ]
机构
[1] Zhejiang Univ, Coll Life Sci, Sperm Lab, Hangzhou, Peoples R China
[2] Zhejiang Univ, Coll Life Sci, Sperm Lab, Hangzhou 310058, Peoples R China
基金
中国国家自然科学基金;
关键词
Sodium channel toxins; Potassium channel toxins; Cytolysin; Organs; Diseases; AMINO-ACID-SEQUENCE; POTASSIUM-CHANNEL TOXIN; POLYPEPTIDE ANTHOPLEURIN-B; SINGLE SODIUM-CHANNELS; HIGH-AFFINITY BINDING; ISOLATED RAT-HEART; MEMORY T-CELLS; EQUINATOXIN-II; ACTINIA-EQUINA; ATX-II;
D O I
10.14670/HH-18-500
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
There are two kinds of toxins in sea anemones: neurotoxins and pore forming toxins. As a representative of the sodium channel toxin, the neurotoxin ATX II in neurotoxin mainly affects the process of action potential and the release of transmitter to affect the inactivation of the sodium channel. As the representatives of potassium channel toxins, BgK and ShK mainly affect the potassium channel current. EqTx and Sticholysins are representative of pore forming toxins, which can form specific ion channels in cell membranes and change the concentration of internal and external ions, eventually causing hemolytic effects. Based on the above mechanism, toxins such as ATX II can also cause toxic effects in tissues and organs such as heart, lung and muscle. As an applied aspect it was shown that sea anemone toxins often have strong toxic effects on tumor cells, induce cancer cells to enter the pathway of apoptosis, and can also bind to monoclonal antibodies or directly inhibit relevant channels for the treatment of autoimmune diseases.
引用
收藏
页码:9 / 28
页数:20
相关论文
共 50 条
  • [21] Development of New Anti-tuberculosis Drug Candidates
    Shi, Ruiru
    Sugawara, Isamu
    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 221 (02): : 97 - 106
  • [22] Venom Peptide Toxins Targeting the Outer Pore Region of Transient Receptor Potential Vanilloid 1 in Pain: Implications for Analgesic Drug Development
    Hwang, Sung-Min
    Jo, Youn-Yi
    Cohen, Cinder Faith
    Kim, Yong-Ho
    Berta, Temugin
    Park, Chul-Kyu
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (10)
  • [23] Crystal structure of leucotoxin S component -: New insight into the staphylococcal β-barrel pore-forming toxins
    Guillet, V
    Roblin, P
    Werner, S
    Coraiola, M
    Menestrina, G
    Monteil, H
    Prévost, G
    Mourey, L
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (39) : 41028 - 41037
  • [24] Potential Drug Development Candidates for Human Soil-Transmitted Helminthiases
    Olliaro, Piero
    Seiler, Juerg
    Kuesel, Annette
    Horton, John
    Clark, Jeffrey N.
    Don, Robert
    Keiser, Jennifer
    PLOS NEGLECTED TROPICAL DISEASES, 2011, 5 (06):
  • [25] Rapid conjugation of antibodies to toxins to select candidates for the development of anticancer Antibody-Drug Conjugates (ADCs)
    Hoffmann, Ricarda M.
    Mele, Silvia
    Cheung, Anthony
    Larcombe-Young, Daniel
    Bucaite, Gintare
    Sachouli, Eirini
    Zlatareva, Iva
    Morad, Hassan O. J.
    Marlow, Rebecca
    McDonnell, James M.
    Figini, Mariangela
    Lacy, Katie E.
    Tutt, Andrew J. N.
    Spicer, James F.
    Thurston, David E.
    Karagiannis, Sophia N.
    Crescioli, Silvia
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [26] Rapid conjugation of antibodies to toxins to select candidates for the development of anticancer Antibody-Drug Conjugates (ADCs)
    Ricarda M. Hoffmann
    Silvia Mele
    Anthony Cheung
    Daniel Larcombe-Young
    Gintare Bucaite
    Eirini Sachouli
    Iva Zlatareva
    Hassan O. J. Morad
    Rebecca Marlow
    James M. McDonnell
    Mariangela Figini
    Katie E. Lacy
    Andrew J. N. Tutt
    James F. Spicer
    David E. Thurston
    Sophia N. Karagiannis
    Silvia Crescioli
    Scientific Reports, 10
  • [27] Development of Combination Vaccine Conferring Optimal Protection against Six Pore-Forming Toxins of Staphylococcus aureus
    Zhang, QingFeng
    Jiang, TingTing
    Mao, Xinrui
    Kim, Jae Deog
    Ahn, Dong Ho
    Jung, Yunjin
    Bae, Taeok
    Lee, Bok Luel
    INFECTION AND IMMUNITY, 2021, 89 (10)
  • [28] Therapeutic applications of snake venoms: An invaluable potential of new drug candidates
    Diniz-Sousa, Rafaela
    Caldeira, Cleopatra A. da S.
    Pereira, Soraya S.
    Da Silva, Saulo L.
    Fernandes, Pedro A.
    Teixeira, Luis M. C.
    Zuliani, Juliana P.
    Soares, Andreimar M.
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 238
  • [29] New drug candidates and innovation for HAT: from discovery to promising candidates, illustrated by oxaboroles development
    Ribeill, Y.
    TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2011, 16 : 19 - 19
  • [30] Mannose receptor-derived peptides neutralize pore-forming toxins and reduce inflammation and development of pneumococcal disease
    Subramanian, Karthik
    Iovino, Federico
    Tsikourkitoudi, Vasiliki
    Merkl, Padryk
    Ahmed, Sultan
    Berry, Samuel B.
    Aschtgen, Marie-Stephanie
    Svensson, Mattias
    Bergman, Peter
    Sotiriou, Georgios A.
    Henriques-Normark, Birgitta
    EMBO MOLECULAR MEDICINE, 2020, 12 (11)