Polydatin Extracted from Polygonum cuspidatum Sieb. et Zucc. Alleviates Acute Kidney Injury in Mice with Sepsis

In this study, polydatin was extracted from Polygonum cuspidatum Sieb.et Zucc. and its alleviative effect on acute kidney injury in mice with sepsis was explored. Sixty mice were randomly divided into control, model and treatment groups, 20 mice in each group. The sepsis model was established in latter two groups. Then, the treatment group was treated with 40 mg/kg polydatin by injection through the tail vein. After 12 h from treatment, compared with control group, in treatment group the serum creatinine and blood urea nitrogen levels were significantly decreased, the kidney water content and kidney injury score were significantly lowered, the kidney tissue tumor necrosis factor alpha, interleukin 6 and interleukin 1 beta levels were significantly decreased, the kidney tissue superoxide dismutase and glutathione levels were significantly increased, the kidney tissue malondialdehyde level was significantly decreased, the kidney tissue B -cell lymphoma -2 protein expression level was significantly increased, and the kidney tissue B-celllymphoma-2 associated X and cysteinyl aspartate specific proteinase-3 protein expression levels were significantly decreased (all p < 0.05). In conclusion, polydatin from Polygonum cuspidatum Sieb.et Zucc. can alleviate the acute kidney injury in mice with sepsis. The action mechanism may be its reduction of inflammatory response, decrease of oxidative stress and inhibition of cell apoptosis in kidney tissues.