Interplay of degeneracy and non-degeneracy in fluctuation propagation in coherent feed-forward loop motif

被引：0
|
作者：
Roy, Tuhin Subhra [1 ]
Nandi, Mintu [2 ]
Chaudhury, Pinaki [3 ]
Chattopadhyay, Sudip [2 ]
Banik, Suman K. [1 ]
机构：
[1] Bose Inst, Dept Chem, 93-1 APC Rd, Kolkata 700009, India
[2] Indian Inst Engn Sci & Technol, Dept Chem, Sibpur 711103, Howrah, India
[3] Univ Calcutta, Dept Chem, 92 APC Rd, Kolkata 700009, India
来源：
JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT | 2023年 / 2023卷 / 09期
关键词：
Gene transcription regulatory network; Feed-forward loop; Langevin equation; Noise decomposition; GENE-EXPRESSION; NETWORK MOTIFS; TRANSCRIPTIONAL REGULATION; NOISE; STOCHASTICITY; TIME;
D O I：
10.1088/1742-5468/acf8b9
中图分类号：
O3 [力学];
学科分类号：
08 ; 0801 ;
摘要：
We present a stochastic framework to decipher fluctuation propagation in classes of coherent feed-forward loops (CFFLs). The systematic contribution of the direct (one-step) and indirect (two-step) pathways is considered to quantify fluctuations of the output node. We also consider both additive and multiplicative integration mechanisms of the two parallel pathways (one-step and two-step). Analytical expression of the output node's coefficient of variation shows contributions of intrinsic, one-step, two-step, and cross-interaction in closed form. We observe a diverse range of degeneracy and non-degeneracy in each of the decomposed fluctuation terms and their contribution to the overall output fluctuations of each CFFL motif. The analysis of output fluctuations reveals a maximal level of fluctuations of the CFFL motif of type 1.
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页数：21
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