Highly selective detection and imaging of glyoxal through a novel fluorescent probe

被引：4

作者：

Wu, Huan ^{[1
]}

Gong, Xiu-Lin ^{[1
]}

Tian, Yang ^{[1
]}

Zheng, Jianfeng ^{[1
]}

Tan, Rui ^{[1
]}

Peng, Yu ^{[1
]}

Wang, Ya-Wen ^{[1
]}

机构：

[1] Southwest Jiaotong Univ, Sch Chem, Chengdu 610031, Peoples R China

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2024年 / 405卷

关键词：

Fluorescent probe; Glyoxal; Specific detection; Turn; -on; Imaging; METHYLGLYOXAL; DETOXIFICATION; PROTEINS; STRESS; WINE;

D O I：

10.1016/j.snb.2024.135362

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A fluorescent probe (SWJT-18) based on o-phenylenediamine derivative was developed for the specific detection of glyoxal (GO). The probe shows an excellent fluorescence turn-on sensing and a visible colorimetric response to GO. And it exhibited high selectivity, rapid response time (15 min) and a low detection limit (0.34 mu M). Notably, SWJT-18 was the first example for detection of GO only without interference of other aldehydes. Its sensing mechanism for GO was confirmed by 1H NMR, LC-MS and density functional theory calculations. In addition, this probe has been successfully applied to imaging of exogenous GO in HeLa cells.

引用

页数：8

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