Applications of Degradable Hydrogels in Novel Approaches to Disease Treatment and New Modes of Drug Delivery

被引:9
|
作者
Hu, Bo [1 ,2 ]
Gao, Jinyuan [1 ,2 ]
Lu, Yu [1 ,2 ,3 ]
Wang, Yuji [1 ,2 ,3 ]
机构
[1] Capital Med Univ, Coll Pharmaceut Sci, Dept Med Chem, Beijing 100069, Peoples R China
[2] Minist Educ China, Engn Res Ctr Endogenous Prophylact, Beijing Area Major Lab Peptide & Small Mol Drugs, Beijing Lab Biomed Mat, Beijing 100069, Peoples R China
[3] Capital Med Univ, Lab Clin Med, Beijing 100069, Peoples R China
关键词
degradable; hydrogels; drug delivery; disease treatment; STEM-CELLS; CANCER-IMMUNOTHERAPY; INJECTABLE HYDROGELS; BONE REGENERATION; CARDIOVASCULAR-DISEASE; POTENTIAL APPLICATIONS; PHOTODYNAMIC THERAPY; ALGINATE HYDROGEL; TRAUMATIC BRAIN; HYALURONIC-ACID;
D O I
10.3390/pharmaceutics15102370
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Hydrogels are particularly suitable materials for loading drug delivery agents; their high water content provides a biocompatible environment for most biomolecules, and their cross-linked nature protects the loaded agents from damage. During delivery, the delivered substance usually needs to be released gradually over time, which can be achieved by degradable cross-linked chains. In recent years, biodegradable hydrogels have become a promising technology in new methods of disease treatment and drug delivery methods due to their many advantageous properties. This review briefly discusses the degradation mechanisms of different types of biodegradable hydrogel systems and introduces the specific applications of degradable hydrogels in several new methods of disease treatment and drug delivery methods.
引用
收藏
页数:36
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