Therapeutic applications of hydrogels in oral drug delivery

被引:244
|
作者
Sharpe, Lindsey A. [1 ]
Daily, Adam M. [1 ]
Horava, Sarena D. [2 ]
Peppas, Nicholas A. [1 ,2 ,3 ]
机构
[1] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA
[2] Univ Texas Austin, Dept Chem Engn, Austin, TX 78712 USA
[3] Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA
关键词
controlled release; drug delivery; hydrogel; intelligent system; oral delivery; PH-SENSITIVE HYDROGELS; COMPLEXATION POLYMER HYDROGELS; TASTE-MASKING TECHNOLOGIES; CACO-2 CELL MONOLAYERS; N-TRIMETHYL CHITOSAN; IN-VITRO EVALUATION; EVERTED GUT SAC; CONTROLLED-RELEASE; INTRACELLULAR DELIVERY; RESPONSIVE HYDROGELS;
D O I
10.1517/17425247.2014.902047
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Introduction: Oral delivery of therapeutics, particularly protein-based pharmaceutics, is of great interest for safe and controlled drug delivery for patients. Hydrogels offer excellent potential as oral therapeutic systems due to inherent biocompatibility, diversity of both natural and synthetic material options and tunable properties. In particular, stimuli-responsive hydrogels exploit physiological changes along the intestinal tract to achieve site-specific, controlled release of protein, peptide and chemotherapeutic molecules for both local and systemic treatment applications. Areas covered: This review provides a wide perspective on the therapeutic use of hydrogels in oral delivery systems. General features and advantages of hydrogels are addressed, with more considerable focus on stimuli-responsive systems that respond to pH or enzymatic changes in the gastrointestinal environment to achieve controlled drug release. Specific examples of therapeutics are given. Last, in vitro and in vivo methods to evaluate hydrogel performance are discussed. Expert opinion: Hydrogels are excellent candidates for oral drug delivery, due to the number of adaptable parameters that enable controlled delivery of diverse therapeutic molecules. However, further work is required to more accurately simulate physiological conditions and enhance performance, which is important to achieve improved bioavailability and increase commercial interest.
引用
收藏
页码:901 / 915
页数:15
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