Structure of prolylrapamycin: confirmation through a revised and detailed NMR assignment study

被引：0

作者：

Mortoni, Annalisa ^{[1
]}

Castelli, Eugenio ^{[1
]}

Recca, Teresa ^{[2
]}

Quadrelli, Paolo ^{[3
]}

机构：

[1] Curia Italy Srl, Via Volturno 43, I-20089 Rozzano, MI, Italy

[2] Univ Pavia, Ctr Grandi Strumenti CGS, Via Bassi 21, I-27100 Pavia, Italy

[3] Univ Pavia, Dipartimento Chim, Viale Taramelli 12, I-27100 Pavia, Italy

来源：

JOURNAL OF ANTIBIOTICS | 2024年 / 77卷 / 06期

关键词：

RAPAMYCIN;

D O I：

10.1038/s41429-024-00714-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A complete and detailed characterization of Rapamycin (1) and Prolylrapamycin (2) has been conducted by homo- and hetero-nuclear NMR experiments in DMSO-d6 along with HRMS and FT-IR spectra and DSCs analyses. The NMR experiments allowed the assignment of every single proton and carbon atom belonging to the two structures and the definitive confirm of the presence of a pyrrolidine ring in Prolylrapamycin (2) in place of the piperidine ring that characterizes the structure of Sirolimus.

引用

页码：345 / 352

页数：8

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