This study investigated the relationship between depressive and anxiety symptoms and psychological resilience among individuals in Sanliurfa during the COVID-19 pandemic. It employed a cross-sectional design with 1,632 participants (704 women, 928 men) aged 18-65 in Sanliurfa province. The study used various measures, including a Demographic Information Form, Beck Depression Scale, Beck Anxiety Scale, and Psychological Resilience Scale for Adults. The analysis included comparing participants' sociodemographic characteristics with their scores on the mentioned scales, using tests like the Independent Sample t- test and ANOVA. Additionally, Pearson tests were used to assess correlations between scores on the Beck Depression Scale, Beck Anxiety Scale, and Psychological Resilience Scale for Adults, while regression analysis was employed to predict scale scores. The findings revealed that women, young adults, high school graduates, single individuals, those without children, individuals with lower incomes, those who owned their homes with family support, people with physical or psychological illnesses, alcohol users, and those who had experimented with psychoactive substances exhibited higher scores on the Beck Depression and Beck Anxiety Scales. Conversely, participants with higher levels of psychological resilience tended to experience fewer depressive and anxiety symptoms. In conclusion, the study highlighted the role of psychological resilience in mitigating depressive and anxiety symptoms during the COVID-19 pandemic. The results suggest the importance of developing interventions that promote psychological resilience, especially in the post-pandemic period. Further research is recommended to explore strategies for enhancing psychological resilience in individuals facing pandemic-related stressors.