Increased oligomeric TDP-43 in the plasma of Korean frontotemporal dementia patients with semantic dementia

被引:5
|
作者
Jamerlan, Angelo M. [1 ]
Shim, Kyu Hwan [1 ]
Youn, Young Chul [2 ]
Teunissen, Charlotte [3 ]
An, Seong Soo A. [1 ]
Scheltens, Philip [4 ,5 ]
Kim, SangYun [6 ,7 ]
机构
[1] Gachon Univ, Bionano Res Inst, Dept Bionano Technol, Seongnam Si, Gyeonggi Do, South Korea
[2] Chung Ang Univ Hosp, Dept Neurol, Seoul, South Korea
[3] Vrije Univ Amsterdam, Amsterdam UMC, Neurochem Lab, Dept Clin Chem,Amsterdam Neurosci, Amsterdam, Netherlands
[4] Univ Amsterdam, Med Ctr, Dept Neurol, Amsterdam, Netherlands
[5] Univ Amsterdam, Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands
[6] Seoul Natl Univ, Bundang Hosp, Dept Neurol, Seongnam Si 13620, Gyeonggi Do, South Korea
[7] Seoul Natl Univ, Coll Med, Suwon, Gyeonggi Do, South Korea
基金
新加坡国家研究基金会;
关键词
aggregation; antibodies; diagnosis; elisa; epitope; immunoassay; monomer; multimer detection system; oligomer; semantic dementia; TDP-43; LOBAR DEGENERATION; CONSENSUS; PROTEIN; DISEASE;
D O I
10.1002/alz.13127
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
INTRODUCTION: Semantic dementia (SD) is a progressive neurodegenerative disease associated with impaired vocabulary that progresses to memory impairment. Post-mortem immunohistochemical analysis is the current reliable method of differentiating TDP-43 deposits in cortical tissue; no means of antemortem diagnosis exists in biofluids, let alone in plasma. METHODS: Here the multimer detection system (MDS) was used to quantify the oligomeric TDP-43 (o-TDP-43) concentrations in plasma of Korean SD patients (n = 16, 6 male, 10 female, ages 59-87). The o-TDP-43 concentrations were compared with the total TDP-43 (t-TDP-43) concentrations quantified through conventional enzyme-linked immunosorbent assay (ELISA). RESULTS AND DISCUSSION: Only MDS showed a significant increase in o-TDP-43 concentrations in the plasma of patients with SD compared to other neurodegenerative disorders and normal controls (p < 0.05). Based on these results, o-TDP-43 concentrations through the application of MDS may be a useful plasma biomarker in SD-FTD (frontotemporal dementia) diagnosis.
引用
收藏
页码:4020 / 4027
页数:8
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