The role of HBV cccDNA in occult hepatitis B virus infection

被引：6
|
作者：
He, Pei [1 ,2 ,3 ]
Zhang, Peixin [3 ]
Fang, Yaping [4 ]
Han, Ning [4 ]
Yang, Wensu [1 ,2 ]
Xia, Zhaoxin [1 ,2 ]
Zhu, Yi [1 ,2 ]
Zhang, Zhenhua [3 ]
Shen, Jilu [1 ,2 ]
机构：
[1] Anhui Med Univ, Dept Lab Med, Affiliated Hosp 1, Hefei 230012, Peoples R China
[2] Anhui Publ Hlth Clin Ctr, Hefei 230012, Peoples R China
[3] Anhui Med Univ, Dept Infect Dis, Hosp 2, Hefei, Peoples R China
[4] Anhui Med Univ, Dept Clin Lab, Hosp 2, Hefei, Peoples R China
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2023年 / 478卷 / 10期
关键词：
Occult hepatitis B; HBV cccDNA kinetics; Cell cycle; Regulation mechanism; Therapy; CLOSED CIRCULAR DNA; EPIGENETIC REGULATION; SURFACE-ANTIGEN; CORE PROTEIN; SERUM HBSAG; REPLICATION; TRANSCRIPTION; DEGRADATION; INHIBITION; LIVER;
D O I：
10.1007/s11010-023-04660-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Occult hepatitis B virus (HBV) infection (OBI) refers to the presence of replication-competent HBV DNA in the liver, with or without HBV DNA in the blood, in individuals who tested negative for HBV surface antigen (HBsAg). In this peculiar phase of HBV infection, the covalently closed circular DNA (cccDNA) is in a low state of replication. Several advances have been made toward clarifying the mechanisms involved in such a suppression of viral activity, which seems to be mainly related to the host's immune control and epigenetic factors. Although the underlying mechanisms describing the genesis of OBI are not completely known, the presence of viral cccDNA, which remains in a low state of replication due to the host's strong immune suppression of HBV replication and gene expression, appears to be the causative factor. Through this review, we have provided an updated account on the role of HBV cccDNA in regulating OBI. We have comprehensively described the HBV cell cycle, cccDNA kinetics, current regulatory mechanisms, and the therapeutic methods of cccDNA in OBI-related diseases.
引用
收藏
页码：2297 / 2307
页数：11
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