A new thiosemicarbazone and its 3d metal complexes: Synthetic, structural, and antioxidant studies

被引：2

作者：

Graur, Ianina ^{[1
]}

Bespalova, Tatiana ^{[1
]}

Graur, Vasilii ^{[1
]}

Tsapkov, Victor ^{[1
]}

Garbuz, Olga ^{[1
]}

Melnic, Elena ^{[2
]}

Bourosh, Pavlina ^{[2
]}

Gulea, Aurelian ^{[1
]}

机构：

[1] Moldova State Univ, Lab Adv Mat Biopharmaceut & Tech, Alexei Mateevici St 60, Kishinev 2009, Moldova

[2] Moldova State Univ, Inst Appl Phys, Lab Phys Methods Solid State Invest Tadeusz Malino, Kishinev, Moldova

来源：

JOURNAL OF CHEMICAL RESEARCH | 2023年 / 47卷 / 06期

关键词：

3d metal complex; amide; antioxidants; pyruvic acid; thiosemicarbazone; PYRUVIC-ACID; BIOLOGICAL-PROPERTIES; COPPER(II) COMPLEXES; CRYSTAL; DERIVATIVES;

D O I：

10.1177/17475198231216422

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-[1-Oxo-1-(piperidin-1-yl)propan-2-ylidene]-N-(prop-2-en-1-yl)hydrazinecarbothioamide (HL) and its six coordination compounds [Cu(L)X] (X = Cl- (1), NO3- (2)), [Cu(A)(L)NO3](A = 1,10-Phen (3), 2,2 '-Bpy (4)), [Ni(HL)2](NO3)2 (5), and [Fe(L)2]Cl (6) are synthesized and characterized by elemental analysis, Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and single-crystal X-ray crystallography. Uncoordinated thiosemicarbazone HL shows higher antioxidant activity against 2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS+center dot) cation radicals compared with most of the other complexes. Complex 5 is the most active and its activity exceeds that of HL and is close to that of trolox, which is used in medicine as an antioxidant. The introduction of N-heteroaromatic bases (1,10-phenanthroline and 2,2 '-bipyridine) into the inner sphere of the complex [Cu(L)NO3] did not lead to an increase in antioxidant activity.

引用

页数：8

共 50 条

[21] Studies on some 3d metal complexes - Synthesis, spectroscopic characterization and biological studies
Thomas, Preethy Soosan
Philip, Surya
Bini, B. S.
Mohanan, K.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2018, 95 (05) : 517 - 526
[22] THIOSEMICARBAZONE COMPLEXES OF COPPER(II) - STRUCTURAL AND BIOLOGICAL STUDIES
WEST, DX
LIBERTA, AE
PADHYE, SB
CHIKATE, RC
SONAWANE, PB
KUMBHAR, AS
YERANDE, RG
COORDINATION CHEMISTRY REVIEWS, 1993, 123 (1-2) : 49 - 71
[23] Synthetic, structural, and antimicrobial studies of organotin(IV) complexes of semicarbazone, thiosemicarbazone derived from 4-hydroxy-3-methoxybenzaldehyde
H. L. Singh
J. B. Singh
K. P. Sharma
Research on Chemical Intermediates, 2012, 38 : 53 - 65
[24] Synthetic, structural, and antimicrobial studies of organotin(IV) complexes of semicarbazone, thiosemicarbazone derived from 4-hydroxy-3-methoxybenzaldehyde
Singh, H. L.
Singh, J. B.
Sharma, K. P.
RESEARCH ON CHEMICAL INTERMEDIATES, 2012, 38 (01) : 53 - 65
[25] Structural and biological studies of mononuclear metal (II) complexes containing hetero ligand based on 3-acetylpyridine thiosemicarbazone
BenGuzzi, Salima A.
S. Abubakr, Amrajaa
Hassan, Safaa S.
APPLIED ORGANOMETALLIC CHEMISTRY, 2023, 37 (09)
[26] FERROCENYL THIOSEMICARBAZONE AND ITS TRANSITION-METAL COMPLEXES
ZHOU, XX
LIANG, YM
NAN, FJ
MA, YX
POLYHEDRON, 1992, 11 (04) : 447 - 451
[27] Synthesis, Structural, and Antibacterial Studies of Some Transition Metal Complexes Derived from Thiosemicarbazone and Semicarbazone
Chandra, Sulekh
Tyagi, Monika
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2009, 184 (03) : 778 - 789
[28] STRUCTURAL STUDIES OF 4(PHENYL-1-CYCLOHEXANONE-3-THIOSEMICARBAZONE OR BENZAMIDO)-4-CYCLOHEXANONE-3-THIOSEMICARBAZONE COMPLEXES
ABUELREASH, GM
IBRAHIM, KM
ELSHAZLY, RE
BEKHEIT, MM
ACTA CHIMICA HUNGARICA-MODELS IN CHEMISTRY, 1990, 127 (01): : 21 - 27
[29] STUDIES ON THIOAMIDOPYRIDINE COMPLEXES OF SOME 3D BIVALENT-METAL IONS
SINGH, B
SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY, 1987, 17 (05): : 457 - 468
[30] SYNTHETIC AND STRUCTURAL STUDIES ON ORGANOTRANSITION-METAL INDIUM THIOCYANATE COMPLEXES
CARMALT, CJ
NORMAN, NC
PEMBER, RF
FARRUGIA, LJ
POLYHEDRON, 1995, 14 (03) : 417 - 424

← 1 2 3 4 5 →