Inhibitory effect of trans-tiliroside on very low-density lipoprotein secretion in HepG2 cells and mouse liver

被引：1
|
作者：
Nagatomo, Akifumi [1 ,2 ]
Kohno, Mamiko [2 ]
Kawakami, Hirosato [2 ]
Manse, Yoshiaki [1 ]
Morikawa, Toshio [1 ,3 ]
机构：
[1] Kindai Univ, Pharmaceut Res & Technol Inst, 3-4-1 Kowakae, Higashi Osaka, Osaka 5778502, Japan
[2] Morishita Jintan Co Ltd, 11-1 Tsudayamate 2 Chome, Hirakata, Osaka 5730128, Japan
[3] Kindai Univ, Antiaging Ctr, 3-4-1 Kowakae, Higashi Osaka, Osaka 5778502, Japan
来源：
JOURNAL OF NATURAL MEDICINES | 2024年 / 78卷 / 01期
关键词：
Trans-tiliroside; Rose hip; Cholesterol; VLDL; Dyslipidemia; Apoprotein; TRIGLYCERIDE TRANSFER PROTEIN; GLUCOSYL HESPERIDIN; LIPID-METABOLISM; ROSE HIP; APO-B; FLAVONOIDS; DIET; RISK; ATHEROSCLEROSIS; HESPERETIN;
D O I：
10.1007/s11418-023-01756-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An acylated flavonol glycoside, trans-tiliroside (1), is found in certain parts of different herbs, including the seeds of Rosa canina (Rosaceae). Previous studies on compound 1 have focused on triglyceride (TG) metabolism, including its anti-obesity and intracellular TG reduction effects. In the present study, the effects of compound 1 on cholesterol (CHO) metabolism were investigated using human hepatocellular carcinoma-derived HepG2 cells and mice. Compound 1 decreased CHO secretion in HepG2 cells, which was enhanced by mevalonate in a concentration-dependent manner and decreased the secretion of apoprotein B (apoB)-100, a marker of very low-density lipoprotein (VLDL). Compound 1 also inhibited the activity of microsomal triglyceride transfer proteins, which mediate VLDL formation from cholesterol and triglycerides in the liver. In vivo, compound 1 inhibited the accumulation of Triton WR-1339-induced TG in the blood of fasted mice and maintained low levels of apoB-100. These results suggest that compound 1 inhibits the secretion of CHO as VLDL from the liver and has the potential for use for the prevention of dyslipidemia.
引用
收藏
页码：180 / 190
页数：11
相关论文
共 50 条
  • [11] Mechanisms of dysregulation of low-density lipoprotein receptor expression in HepG2 cells induced by inflammatory cytokines
    CHEN Yaxi RUAN Xiongzhong HUANG Ailong LI Qiu John FMoorhead Zac Varghese Centre for Lipid ResearchKey Laboratory of Molecular Biology on Infectious DiseasesMinistry of Education
    Second Affiliated HospitalChongqing Medical UniversityChongqing China Chen YXRuan XZHuang AL and Li QCentre for NephrologyRoyal Free and University College Medical SchoolRoyal Free CampusLondonUK Moorhead JF and Varghese Z
    Chinese Medical Journal, 2007, 120 (24) : 2185 - 2190
  • [12] Mechanisms of dysregulation of low-density lipoprotein receptor expression in HepG2 cells induced by inflammatory cytokines
    CHEN Ya-xi RUAN Xiong-zhong HUANG Ai-long LI Qiu John F.Moorhead Zac Varghese Centre for Lipid Research
    Second Affiliated Hospital
    中华医学杂志(英文版), 2007, (24) : 2185 - 2190
  • [13] Mechanisms of dysregulation of low-density lipoprotein receptor expression in HepG2 cells induced by inflammatory cytokines
    Chen Ya-xi
    Ruan Xiong-zhong
    Huang Ai-long
    Li Qiu
    Moorhead, John R.
    Varghese, Zac
    CHINESE MEDICAL JOURNAL, 2007, 120 (24) : 2185 - 2190
  • [14] Effects of edible tropical plant extracts on inhibiting copper-mediated low-density lipoprotein oxidation and upregulating low-density lipoprotein receptor in HepG2 cells
    Salleh, MN
    Runnie, I
    Roach, PD
    Mohamed, S
    Head, RJ
    Abeywardena, MY
    FREE RADICAL RESEARCH, 2003, 37 : 69 - 69
  • [15] Inhibition of low density lipoprotein oxidation and upregulation of the low density lipoprotein receptor of human liver Hepg2 cells by tropical plant extracts
    Roach, PD
    Salleh, MN
    Runnie, I
    Mohamed, S
    Abeywardena, MY
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2003, 30 (5-6) : A8 - A8
  • [16] COUPLED SECRETION OF VERY LOW-DENSITY LIPOPROTEIN APOPEPTIDES AND ACYLGLYCEROLS BY THE LIVER-CELL
    JANERO, DR
    SIUTAMANGANO, P
    LANE, MD
    JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1983, 60 (04) : 727 - 727
  • [17] Oxidative modification of low-density lipoprotein by the human hepatoma cell line HepG2
    Pico, I
    Myara, I
    PechAmsellem, MA
    Vedie, B
    Chappey, B
    Moatti, N
    FREE RADICAL RESEARCH, 1996, 25 (04) : 321 - 336
  • [18] Low density lipoprotein-receptor plays a major role in the binding of very low density lipoproteins and their remnants on HepG2 cells
    Truong, TQ
    Falstrault, L
    Tremblay, C
    Brissette, L
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1999, 31 (06): : 695 - 705
  • [19] SYNTHESIS, PROCESSING, AND SECRETION OF HEPATIC VERY LOW-DENSITY LIPOPROTEIN
    JANERO, DR
    SIUTAMANGANO, P
    MILLER, KW
    LANE, MD
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1984, 24 (02) : 131 - 152
  • [20] SYNTHESIS, ASSEMBLY, AND SECRETION OF HEPATIC VERY LOW-DENSITY LIPOPROTEIN
    LANE, MD
    JANERO, DR
    SIUTAMANGANO, P
    MILLER, KW
    ARZTLICHE LABORATORIUM, 1988, 34 (01): : 33 - 42
12345