Spontaneous reduction of iron(iii)porphyrin to iron(ii)porphyrin-CO complex in mouse circulation

被引：1
|
作者：
Noguchi, Masataka [1 ]
Mao, Qiyue [1 ]
Nakagami, Atsuki [1 ]
Kitagishi, Hiroaki [1 ]
机构：
[1] Doshisha Univ, Fac Sci & Engn, Dept Mol Chem & Biochem, Kyotanabe, Kyoto 6100321, Japan
来源：
CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 41期
关键词：
CARBON-MONOXIDE; IRON PORPHYRIN; HEMOGLOBIN; METHEMOGLOBIN; MYOGLOBIN; MECHANISM;
D O I：
10.1039/d3cc00420a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Iron(ii/iii)porphyrin/cyclodextrin inclusion complexes serve as hemoprotein models in vivo. Here we showed the iron(iii)porphyrin complex to be spontaneously reduced to its iron(ii) state in mouse circulation. The reduced complex bound endogenous CO from carboxyhemoglobin, which was followed by urinary excretion. The natural reduction system was found to be effective for synthetic heme-model compounds.
引用
收藏
页码：6211 / 6214
页数：4
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