Single-Cell Mutation Profiling and Alternative Splicing Analysis Reveals Distinct Aberrant Splicing of U2AF1 S34 and U2AF1 Q157 in Myeloid Malignancies

被引:0
|
作者
Wen, Sean [1 ,2 ]
Sullivan, Jennifer O. [1 ,3 ]
Baxter, Joanna [4 ]
Sousos, Nikolaos [1 ,3 ]
Mead, Adam J. [3 ,5 ]
Rodriguez-Meira, Alba [3 ,6 ,7 ,8 ,9 ]
机构
[1] Univ Oxford, Weatherall Inst Mol Med, Haematopoiet Stem Cell Biol Lab, Med Res Council,Mol Haematol Unit, Cambridge, England
[2] Univ Oxford, Weatherall Inst Mol Med, Med Res Council, Ctr Computat Biol, Oxford, England
[3] Univ Oxford, NIHR Biomed Res Ctr, Oxford, England
[4] Cambridge Univ Hosp NHS Fdn Trust, Dept Haematol, Cambridge, England
[5] Univ Oxford, MRC Weatherall Inst Mol Med, Natl Inst Hlth Res Biomed Res Ctr, MRC,Mol Haematol Unit, Oxford, England
[6] Univ Oxford, MRC, WIMM, Oxford, England
[7] Univ Oxford, NIHR Biomed Res Ctr, Oxford, England
[8] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
[9] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA
关键词
D O I
10.1182/blood-2023-185999
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:4
相关论文
共 50 条
  • [21] U2AF1(S34F) Mutant Hematopoietic Cells Require Expression of Wild-Type U2af1 for Survival
    Wadugu, Brian
    Heard, Amanda
    Bradley, Joseph
    Ndonwi, Matthew
    Shao, Jin J.
    Walter, Matthew J.
    BLOOD, 2018, 132
  • [22] Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival
    Fei, Dennis Liang
    Motowski, Hayley
    Chatrikhi, Rakesh
    Prasad, Sameer
    Yu, Jovian
    Gao, Shaojian
    Kielkopf, Clara L.
    Bradley, Robert K.
    Varmus, Harold
    PLOS GENETICS, 2016, 12 (10):
  • [23] Biological Characterization of the U2af1 S34F Mutation in the Pathogenesis of Myelodysplasia
    Kon, Ayana
    Nannya, Yasuhito
    Nakagawa, Masahiro
    Kataoka, Keisuke
    Sanada, Masashi
    Nakayama, Manabu
    Koseki, Haruhiko
    Ogawa, Seishi
    BLOOD, 2018, 132
  • [24] U2AF1 S34F Mutation Promote Megakaryopoiesis and Fibrogenesis in MDS
    Zhang, Wenjun
    Liu, Jinqin
    Yang, Lin
    Yan, Yiru
    Qin, Tiejun
    Xu, Zefeng
    Huang, Gang
    Li, Bing
    Xiao, Zhijian
    BLOOD, 2023, 142
  • [25] Mutant U2AF1S34F and U2AF1Q157P Induce Distinct RNA Splicing and Hematopoietic Phenotypes In Vivo
    Alberti, Michael O.
    Zhu, Meng'ou
    Srivatsan, Sridhar Nonavinkere
    Ahmed, Tanzir
    Shao, Jin J.
    Wadugu, Brian
    Shirai, Cara Lunn
    Walter, Matthew J.
    BLOOD, 2019, 134
  • [26] Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo
    Shirai, Cara Lunn
    Ley, James N.
    White, Brian S.
    Kim, Sanghyun
    Tibbitts, Justin
    Shao, Jin
    Ndonwi, Matthew
    Wadugu, Brian
    Duncavage, Eric J.
    Okeyo-Owuor, Theresa
    Liu, Tuoen
    Griffith, Malachi
    McGrath, Sean
    Magrini, Vincent
    Fulton, Robert S.
    Fronick, Catrina
    O'Laughlin, Michelle
    Graubert, Timothy A.
    Walter, Matthew J.
    CANCER CELL, 2015, 27 (05) : 631 - 643
  • [27] Impact of U2AF1 Mutations on Clinical Characteristics and RNA Splicing in Myelodysplastic Syndromes (MDS)
    Li, Bing
    Liu, Jinqin
    Qin, Tiejun
    Xu, Zefeng
    Huang, Gang
    Xiao, Zhijian
    BLOOD, 2019, 134
  • [28] Dysregulated Alternative Splicing in Inv(16) Acute Myeloid Leukemia Via U2AF1 Deacetylation during DNA Damage Response
    Zhang, Lianjun
    Fu, Yu-Hsuan
    Hua, Wei-Kai
    Le Xuan Truong Nguyen
    Zhu, Yinghui
    Chen, Ying-Chieh
    He, Xin
    Li, Man
    Dong, Haojie
    Zhang, Bin
    Li, Ling
    Stark, Jeremy
    Marcucci, Guido
    Kuo, Ya-Huei
    BLOOD, 2023, 142
  • [29] U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing
    T Okeyo-Owuor
    B S White
    R Chatrikhi
    D R Mohan
    S Kim
    M Griffith
    L Ding
    S Ketkar-Kulkarni
    J Hundal
    K M Laird
    C L Kielkopf
    T J Ley
    M J Walter
    T A Graubert
    Leukemia, 2015, 29 : 909 - 917
  • [30] High-Resolution Binding Atlas of U2AF1 Mutants Uncovers New Complexity in Splicing Alterations and Kinetics in Myeloid Malignancies
    Biancon, Giulia
    Joshi, Poorval
    Hunck, Torben
    Zimmer, Josh
    Gao, Yimeng
    Machyna, Martin
    Botti, Valentina
    Qin, Ashley
    Viero, Gabriella
    Neuenkirchen, Nils
    Taylor, Ashley
    Gbyli, Rana
    Patel, Amisha
    Ardasheva, Anastasia
    Fu, Xiaoying
    Lin, Haifan
    Simon, Matthew D.
    Neugebauer, Karla M.
    Tebaldi, Toma
    Halene, Stephanie
    BLOOD, 2020, 136