Single-Cell Mutation Profiling and Alternative Splicing Analysis Reveals Distinct Aberrant Splicing of U2AF1 S34 and U2AF1 Q157 in Myeloid Malignancies

被引：0
|
作者：
Wen, Sean [1 ,2 ]
Sullivan, Jennifer O. [1 ,3 ]
Baxter, Joanna [4 ]
Sousos, Nikolaos [1 ,3 ]
Mead, Adam J. [3 ,5 ]
Rodriguez-Meira, Alba [3 ,6 ,7 ,8 ,9 ]
机构：
[1] Univ Oxford, Weatherall Inst Mol Med, Haematopoiet Stem Cell Biol Lab, Med Res Council,Mol Haematol Unit, Cambridge, England
[2] Univ Oxford, Weatherall Inst Mol Med, Med Res Council, Ctr Computat Biol, Oxford, England
[3] Univ Oxford, NIHR Biomed Res Ctr, Oxford, England
[4] Cambridge Univ Hosp NHS Fdn Trust, Dept Haematol, Cambridge, England
[5] Univ Oxford, MRC Weatherall Inst Mol Med, Natl Inst Hlth Res Biomed Res Ctr, MRC,Mol Haematol Unit, Oxford, England
[6] Univ Oxford, MRC, WIMM, Oxford, England
[7] Univ Oxford, NIHR Biomed Res Ctr, Oxford, England
[8] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
[9] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA
来源：
BLOOD | 2023年 / 142卷
关键词：
D O I：
10.1182/blood-2023-185999
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：4
相关论文
共 50 条
  • [1] Splicing Analysis Unveils Convergent Transcriptomic Pathways in U2AF1 S34 and Q157 Mutant Myeloid Neoplasia
    Gurnari, Carmelo
    Durmaz, Arda
    Awada, Hussein
    Ogbue, Olisaemeka
    Kubota, Yasuo
    Kewan, Tariq
    Bahaj, Waled
    Yang, Chao-Yie
    Scott, Jacob
    Haferlach, Torsten
    Maciejewski, Jaroslaw P.
    Visconte, Valeria
    BLOOD, 2022, 140 : 6890 - 6891
  • [2] U2AF1 Mutations in S34 and Q157 Create Distinct Molecular and Clinical Contexts
    Adema, Vera
    Hirsch, Cassandra M.
    Przychodzen, Bartlomiej P.
    Nazha, Aziz
    Kuzmanovic, Teodora
    Negoro, Eiju
    You, Dewen
    Makishima, Hideki
    Clemente, Michael J.
    Carraway, Hetty E.
    Sekeres, Mikkael A.
    Visconte, Valeria
    Maciejewski, Jaroslaw P.
    BLOOD, 2016, 128 (22)
  • [3] The Biological and Clinical Consequences of RNA Splicing Factor U2AF1 Mutation in Myeloid Malignancies
    Zhao, Yangjing
    Cai, Weili
    Hua, Ye
    Yang, Xiaochen
    Zhou, Jingdong
    CANCERS, 2022, 14 (18)
  • [4] Alternative splicing of U2AF1 reveals a shared repression mechanism for duplicated exons
    Kralovicova, Jana
    Vorechovsky, Igor
    NUCLEIC ACIDS RESEARCH, 2017, 45 (01) : 417 - 434
  • [5] U2AF1 Splicing Factor Mutations Affect RNA Subcellular Compartmentalization in Myeloid Malignancies
    Biancon, Giulia
    Busarello, Emma
    Lessard, Mark D.
    Courvan, Edward
    Escayola, Dahyana Arias
    VanOudenhove, Jennifer
    Lee, Veronica
    Krick, Mathew
    Bewersdorf, Joerg
    Neugebauer, Karla M.
    Tebaldi, Toma
    Halene, Stephanie
    BLOOD, 2022, 140 : 1271 - 1272
  • [6] Allele-Specific Effects Of U2AF1 Mutations On Alternative Splicing
    Okeyo-Owuor, Theresa
    White, Brian S.
    Mohan, Dipika
    Griffith, Malachi
    Walter, Matthew J.
    Graubert, Timothy
    BLOOD, 2013, 122 (21)
  • [7] Somatic U2AF1 Mutations Involving Codons Q157 and S34 are Associated with Distinct Clinical and Molecular Characteristics but Similar Outcomes in Patients with Myelodysplastic Syndrome
    Qiu, Lianqun
    Garcia-Manero, Guillermo
    Montalban-Bravo, Guillermo
    Yang, Hui
    Tang, Zhenya
    Patel, Keyur
    Loghavi, Sanam
    Ok, Chi Young
    Bueso-Ramos, Carlos
    Medeiros, L. Jeffrey
    Kanagal-Shamanna, Rashmi
    LABORATORY INVESTIGATION, 2022, 102 (SUPPL 1) : 1004 - 1005
  • [8] Integrative Profiling of Alternative Splicing Induced by U2AF1 S34F Mutation in Lung Adenocarcinoma Reveals a Mechanistic Link to Mitotic Stress
    Kim, Suyeon
    Park, Charny
    Jun, Yukyung
    Lee, Sanghyuk
    Jung, Yeonjoo
    Kim, Jaesang
    MOLECULES AND CELLS, 2018, 41 (08) : 733 - 741
  • [9] Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
    Graubert, Timothy A.
    Shen, Dong
    Ding, Li
    Okeyo-Owuor, Theresa
    Lunn, Cara L.
    Shao, Jin
    Krysiak, Kilannin
    Harris, Christopher C.
    Koboldt, Daniel C.
    Larson, David E.
    McLellan, Michael D.
    Dooling, David J.
    Abbott, Rachel M.
    Fulton, Robert S.
    Schmidt, Heather
    Kalicki-Veizer, Joelle
    O'Laughlin, Michelle
    Grillot, Marcus
    Baty, Jack
    Heath, Sharon
    Frater, John L.
    Nasim, Talat
    Link, Daniel C.
    Tomasson, Michael H.
    Westervelt, Peter
    DiPersio, John F.
    Mardis, Elaine R.
    Ley, Timothy J.
    Wilson, Richard K.
    Walter, Matthew J.
    NATURE GENETICS, 2012, 44 (01) : 53 - U77
  • [10] Somatic U2AF1 Mutations Involving Codons Q157 and S34 are Associated with Distinct Clinical and Molecular Characteristics but Similar Outcomes in Patients with Myelodysplastic Syndrome
    Qiu, Lianqun
    Garcia-Manero, Guillermo
    Montalban-Bravo, Guillermo
    Yang, Hui
    Tang, Zhenya
    Patel, Keyur
    Loghavi, Sanam
    Ok, Chi Young
    Bueso-Ramos, Carlos
    Medeiros, L. Jeffrey
    Kanagal-Shamanna, Rashmi
    MODERN PATHOLOGY, 2022, 35 (SUPPL 2) : 1004 - 1005
12345