Synthesis of Metabolites and Metabolite-like Compounds Using Biocatalytic Systems

被引:1
|
作者
Wohlgemuth, Roland [1 ,2 ,3 ]
机构
[1] Lodz Univ Technol, Inst Appl Radiat Chem, Fac Chem, MITR, Zeromskiego St 116, PL-90924 Lodz, Poland
[2] Swiss Coordinat Comm Biotechnol SKB, CH-8021 Zurich, Switzerland
[3] European Soc Appl Biocatalysis ESAB, B-1000 Brussels, Belgium
关键词
metabolite synthesis; biocatalytic systems; product recovery; isotope-labelled metabolites; metabolite-like compounds; NATURAL-PRODUCTS; ENZYMATIC-SYNTHESIS; AMINO-ACIDS; GLYCEROL DEHYDROGENASE; 25-HYDROXYVITAMIN D-3; BENZOQUINONE IMINE; ONE-STEP; DRUG; HYDROXYLATION; ANALOGS;
D O I
10.3390/metabo13101097
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Methodologies for the synthesis and purification of metabolites, which have been developed following their discovery, analysis, and structural identification, have been involved in numerous life science milestones. The renewed focus on the small molecule domain of biological cells has also created an increasing awareness of the rising gap between the metabolites identified and the metabolites which have been prepared as pure compounds. The design and engineering of resource-efficient and straightforward synthetic methodologies for the production of the diverse and numerous metabolites and metabolite-like compounds have attracted much interest. The variety of metabolic pathways in biological cells provides a wonderful blueprint for designing simplified and resource-efficient synthetic routes to desired metabolites. Therefore, biocatalytic systems have become key enabling tools for the synthesis of an increasing number of metabolites, which can then be utilized as standards, enzyme substrates, inhibitors, or other products, or for the discovery of novel biological functions.
引用
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页数:29
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