Fertility assessment and treatment in adolescent and young adult cancer survivors

被引：2

作者：

Moravek, Molly B. ^{[1
,17
]}

Pavone, Mary Ellen ^{[2
]}

Burns, Karen ^{[3
,4
]}

Kashanian, James A. ^{[5
]}

Anderson, Richard A. ^{[6
]}

Klosky, James L. ^{[7
,8
]}

Rotz, Seth J. ^{[9
]}

Stern, Catharyn J. ^{[10
,11
]}

Rodriguez-Wallberg, Kenny A. ^{[12
]}

Levine, Jennifer M. ^{[13
,14
]}

Meacham, Lillian R. ^{[15
,16
]}

机构：

[1] Univ Michigan, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Ann Arbor, MI USA

[2] Northwestern Univ, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Feinberg Sch Med, Chicago, IL USA

[3] Cincinnati Childrens Hosp Med Ctr, Canc & Blood Dis Inst, Cincinnati, OH USA

[4] Univ Cincinnati, Dept Pediat, Sch Med, Cincinnati, OH USA

[5] Weill Cornell Med, Dept Urol, New York, NY USA

[6] Univ Edinburgh, MRC Ctr Reprod Hlth, Edinburgh, Scotland

[7] Childrens Healthcare Atlanta, Aflac Canc & Blood Disorders Ctr, Atlanta, GA USA

[8] Emory Univ, Dept Pediat, Sch Med, Atlanta, GA USA

[9] Cleveland Clin Fdn, Div Pediat Hematol Oncol & Bone Marrow Transplanta, Cleveland, OH USA

[10] Melbourne IVF, East Melbourne, Vic, Australia

[11] Royal Womens Hosp, Parkville, Vic, Australia

[12] Karolinska Univ Hosp, Dept Reprod Med, Div Gynecol & Reprod, Solna, Sweden

[13] Cornell Univ Joan, Div Pediat Hematol Oncol, New York, NY USA

[14] Sanford I Weill Med Coll, New York, NY USA

[15] Childrens Healthcare Atlanta, Aflac Canc Ctr, Atlanta, GA USA

[16] Emory Univ, Dept Pediat, Div Hematol Oncol & Endocrinol, Sch Med, Atlanta, GA USA

[17] 475 Market Pl,Bldg 1,Suite B, Ann Arbor, MI 48108 USA

来源：

PEDIATRIC BLOOD & CANCER | 2023年 / 70卷

关键词：

AYA; fertility; reproduction; survivorship; TESTICULAR SPERM EXTRACTION; OVARIAN TISSUE CRYOPRESERVATION; GUIDELINE HARMONIZATION GROUP; ALKYLATING AGENT EXPOSURE; CHILDHOOD-CANCER; FEMALE SURVIVORS; INHIBIN-B; ANTIMULLERIAN HORMONE; PREMATURE MENOPAUSE; ONCOLOGY PATIENTS;

D O I：

10.1002/pbc.28854

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the survivorship setting, adolescent and young adult (AYA) cancer survivors frequently demonstrate little knowledge of infertility risk, are unclear regarding their fertility status, and may under- or overestimate their treatment-related risk for infertility. In female AYA survivors, ovarian function usually parallels fertility, and can be assessed with serum hormone levels and ultrasonography. Posttreatment fertility preservation may be appropriate for survivors at risk for primary ovarian insufficiency. In male AYA survivors, fertility and gonadal function are not always equally affected, and can be assessed with a semen analysis and serum hormones, respectively. As reproductive health issues are commonly cited as an important concern by survivors of AYA cancer, multidisciplinary care teams including oncology, endocrinology, psychology, and reproductive medicine are advocated, with the aim of optimal provision of fertility advice and care for AYA cancer survivors.

引用

页数：9

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