4-Membered Ring Carbocations: A Positive Development in the Synthesis of 3,3-Disubstituted Oxetanes and Azetidines

被引：4

作者：

Rojas, Juan J. ^{[1
]}

Bull, James A. ^{[1
]}

机构：

[1] Imperial Coll London, Dept Chem, London W12 OBZ, England

来源：

CHIMIA | 2023年 / 77卷 / 04期

关键词：

Azetidines; Bioisosteres; Carbocations; Chemical space; Oxetanes; FRIEDEL-CRAFTS ALKYLATION;

D O I：

10.2533/chimia.2023.192

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

4-Membered heterocycles are low molecular weight polar scaffolds with intriguing potential for drug discovery. Despite their unquestionable value, methods to access such heterocycles remain scant. Here, we de-scribe the generation of oxetane-and azetidine-benzylic carbocations as a general strategy to access valuable 3,3-disubstituted derivatives.

引用

页码：192 / 195

页数：4

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