A Potential New Use for Tocilizumab: Refractory Checkpoint Inhibitor Hepatitis

被引:2
|
作者
Lyles, Laine [1 ]
Farmer, Reagan [2 ]
Abougergi, Marwan [3 ]
机构
[1] Univ South Carolina, Prisma Hlth, Columbia, SC 29208 USA
[2] Univ South Carolina, Sch Med Columbia, Columbia, SC USA
[3] Catalyst Med Consulting, Simpsonville, SC USA
关键词
autoimmune hepatitis; drug-induced autoimmune hepatitis; check point inhibitor; chemotherapy; renal cell carcinoma; hepatitis; drug induced liver injury; steroid refractory; tocilizumab; nivolumab; ipilimumab; CANCER;
D O I
10.14309/crj.0000000000001162
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Immune checkpoint inhibitors are becoming more commonly used for many forms of malignancy. With this class of medications being more heavily used, there has been an associated rise in medication-induced autoimmune hepatitis. This case involves a 35-year-old woman being treated with nivolumab/ipilimumab for renal cell carcinoma who developed a steroid-refractory autoimmune hepatitis.
引用
收藏
页数:3
相关论文
共 50 条
  • [1] A Potential New Use for Tocilizumab: A Case of Refractory Checkpoint Inhibitor Hepatitis
    Lyles, Laine A.
    Farmer, Reagan
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2022, 117 (10): : S2082 - S2083
  • [2] Use of tocilizumab for the treatment of steroid and mycophenolate-refractory hepatitis and cholangiohepatitis induced by immune checkpoint inhibitor immunotherapy
    Ling, Sophia
    Jayathilaka, Bishma
    Hui, Chee
    Segal, Jonathan
    Trinh, Andrew
    JOURNAL OF HEPATOLOGY, 2024, 80 : S92 - S93
  • [3] Tocilizumab for refractory severe immune checkpoint inhibitor-associated myocarditis
    Doms, J.
    Prior, J. O.
    Peters, S.
    Obeid, M.
    ANNALS OF ONCOLOGY, 2020, 31 (09) : 1273 - 1275
  • [4] Tofacitinib is Effective in Treating Refractory Immune Checkpoint Inhibitor Hepatitis
    Wang, Mike
    Reynolds, Kerry L.
    Montazeri, Kamaneh
    Schaefer, Esperance A.
    Sullivan, Ryan J.
    Dougan, Michael
    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2024, 22 (07) : 1539 - 1541
  • [5] Tocilizumab for Corticosteroid-Refractory Immune Checkpoint Inhibitor-Induced Generalized Morphea
    Blaise, Manon
    Cardot-Leccia, Nathalie
    Seitz-Polski, Barbara
    Picard-Gauci, Alexandra
    Bertold, Clemence
    Passeron, Thierry
    Montaudie, Henri
    JAMA DERMATOLOGY, 2023, 159 (01) : 112 - 114
  • [6] PREDICTORS AND OUTCOMES OF STEROID-REFRACTORY IMMUNE CHECKPOINT INHIBITOR HEPATITIS
    Li, Michael
    Sack, Jordan
    Rahma, Osama E.
    Grover, Shilpa
    Zucker, Stephen D.
    HEPATOLOGY, 2020, 72 : 85A - 85A
  • [7] Tocilizumab in grade 4 hepatitis secondary to immune checkpoint inhibitor: a case report and review of the literature
    Ali, Syed B.
    Vembar, Preethi
    Sukumaran, Shawgi
    Gunawardane, Dimuth
    Hughes, Tiffany
    Smith, Anthony
    IMMUNOTHERAPY, 2023, 15 (14) : 1125 - 1132
  • [8] Personalized Cytokine-Directed Therapy With Tocilizumab for Refractory Immune Checkpoint Inhibitor-Related Cholangiohepatitis
    Moi, Laura
    Bouchaab, Hasna
    Mederos, Nuria
    Nguyen-Ngoc, Tu
    Perreau, Matthieu
    Fenwick, Craig
    Vaucher, Julien
    Sempoux, Christine
    Peters, Solange
    Obeid, Michel
    JOURNAL OF THORACIC ONCOLOGY, 2021, 16 (02) : 318 - 326
  • [9] CYTOKINE RELEASE STORM FOLLOWING IMMUNE CHECKPOINT INHIBITOR USE MANAGED WITH TOCILIZUMAB IN THE ICU
    Covert, Erin
    Mucha, Simon
    Funchain, Paulime
    CRITICAL CARE MEDICINE, 2023, 51 (01) : 162 - 162
  • [10] Potential radiotherapy-related reactivation of immune checkpoint inhibitor hepatitis
    Yesmembetov, Kakharman
    Sahin, Cennet
    Murad, Mohamad
    Berres, Marie-Luise
    Koch, Alexander
    von Websky, Martin
    Vondran, Florian
    Bruners, Philipp
    Eble, Michael
    Mohamed, Ahmed Allam
    STRAHLENTHERAPIE UND ONKOLOGIE, 2025,