Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis

被引：11
|
作者：
Yan, Li-Hong [1 ,2 ,3 ,4 ]
Li, Xin [1 ,2 ,3 ,5 ]
Wang, Bin-Gui [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Chinese Acad Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
[2] Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
[3] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China
[4] Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
[5] Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
来源：
NATURAL PRODUCT REPORTS | 2023年 / 40卷 / 12期
关键词：
TRICHODERMA CF. BREVICOMPACTUM; CYTOTOXIC MODIFIED DIPEPTIDES; INTERSTRAND CROSS-LINKING; MEK INHIBITOR RO4987655; CONCISE TOTAL-SYNTHESIS; ENDOPHYTIC FUNGUS; PENICILLIUM-JANTHINELLUM; HETEROCYCLIC DIPEPTIDES; ABSOLUTE-CONFIGURATION; MONOTERPENOID INDOLE;
D O I：
10.1039/d3np00023k
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1,2-Oxazine is a heterocyclic scaffold rarely found in natural products and is characterized by a directly connected N-O bond in a six-membered ring. Since the discovery of geneserine, the first 1,2-oxazine-containing natural product (1,2-oxazine NP) being isolated from Calabar bean (Physostigma venenosum) in 1925, a total of 76 naturally occurring 1,2-oxazine NPs have been isolated and identified from various sources, which have attracted the attention of researchers in the field of natural product chemistry, organic synthesis, biosynthesis, and pharmacology. This review summarizes the chemical family of 1,2-oxazine NPs, focusing on their source organisms, structural diversities, chemical synthesis, and biosynthesis.
引用
收藏
页码：1874 / 1900
页数：27
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