The role of non-coding RNAs in muscle aging: regulatory mechanisms and therapeutic potential

被引：4

作者：

Shin, Yeo Jin ^{[1
]}

Kwon, Ki-Sun ^{[1
,2
,3
]}

Suh, Yousin ^{[4
,5
]}

Lee, Kwang-Pyo ^{[1
,2
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol KRIBB, Aging Convergence Res Ctr, Daejeon, South Korea

[2] Korea Univ Sci & Technol UST, KRIBB Sch, Dept Biosci, Daejeon, South Korea

[3] Aventi Inc, Daejeon, South Korea

[4] Columbia Univ, Dept Obstet & Gynecol, New York, NY 10027 USA

[5] Columbia Univ, Dept Genet & Dev, New York, NY 10027 USA

来源：

FRONTIERS IN MOLECULAR BIOSCIENCES | 2024年 / 10卷

基金：

新加坡国家研究基金会;

关键词：

ncRNA; miRNA; lncRNA; circRNA; skeletal muscle; aging; AGE-RELATED-CHANGES; SKELETAL-MUSCLE; CIRCULAR RNAS; CELLULAR SENESCENCE; MICRORNA EXPRESSION; DIFFERENTIATION; DECLINE; ATROPHY;

D O I：

10.3389/fmolb.2023.1308274

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Muscle aging is a complex physiological process that leads to the progressive decline in muscle mass and function, contributing to debilitating conditions in the elderly such as sarcopenia. In recent years, non-coding RNAs (ncRNAs) have been increasingly recognized as major regulators of muscle aging and related cellular processes. Here, we comprehensively review the emerging role of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in the regulation of muscle aging. We also discuss how targeting these ncRNAs can be explored for the development of novel interventions to combat age-related muscle decline. The insights provided in this review offer a promising avenue for future research and therapeutic strategies aimed at improving muscle health during aging.

引用

页数：10

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