Humoral Immune Response of Heterologous ChAdOx1 nCoV-19 and mRNA-1273 Prime-Boost Vaccination against SARS-CoV-2 Variants in Korea

被引：0

作者：

Lim, Heeji ^{[1
]}

Jang, Sundong ^{[1
]}

In, Hyun Ju ^{[1
]}

Kim, Kwangwook ^{[1
]}

Choi, Eun Bee ^{[1
]}

Kim, Soo Ji ^{[1
]}

Lim, Hye Jung ^{[1
]}

Yim, Min Su ^{[1
]}

Ouh, In-ohk ^{[1
]}

Kim, Byung Chul ^{[1
]}

Do, Hyeon Nam ^{[2
]}

Lee, June -Woo ^{[2
]}

Kim, Byoungguk ^{[2
]}

Lee, Yoo-kyoung ^{[1
]}

机构：

[1] Korea Dis Control & Prevent Agcy, Korea Natl Inst Hlth, Ctr Vaccine Res, Div Vaccine Dev Coordinat,Natl Inst Infect Dis, 212 Osongsaengmyoung 2 Ro, Cheongju 28160, Chungcheongbuk, South Korea

[2] Korea Dis Control & Prevent Agcy, Ctr Vaccine Res, Korea Natl Inst Hlth, Div Vaccine Clin Res,Natl Inst Infect Dis, Cheongju, South Korea

来源：

INFECTION AND CHEMOTHERAPY | 2023年 / 55卷 / 01期

关键词：

COVID-19; vaccine; Heterologous vaccination; Immunity; Omicron variant; Korea;

D O I：

10.3947/ic.2022.0132

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The immunogenicity of a heterologous vaccination regimen consisting of ChAdOx1 nCoV-19 (a chimpanzee adenovirus-vectored vaccine) followed by mRNA-1273 (a lipid-nanoparticle-encapsulated mRNA-based vaccine) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), specifically the omicron variant (B.1.1.529), is poorly studied. The aim of this study was to evaluate the neutralizing antibody activity and immunogenicity of heterologous ChAdOx1 nCoV-19 and mRNA-1273 prime-boost vaccination against wild-type (BetaCoV/Korea/KCDC03/2020), alpha, beta, gamma, delta, and omicron variants of SARS-CoV-2 in Korea. A 50% neutralizing dilution (ND50) titer was determined in serum samples using the plaque reduction neutralization test. Antibody titer decreased significantly at 3 months compared with that at 2 weeks after the 2nd dose. On comparing the ND50 titers for the above-mentioned variants of concerns, it was observed that the ND50 titer for the omicron variant was the lowest. This study provides insights into cross-vaccination effects and can be useful for further vaccination strategies in Korea.

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页码：99 / 104

页数：6

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