Disease activity in patients with immune-mediated inflammatory diseases after SARS-CoV-2 vaccinations

被引：13

作者：

van Dam, Koos P. J. ^{[1
]}

Wieske, Luuk ^{[1
,2
]}

Stalman, Eileen W. ^{[1
]}

Kummer, Laura Y. L. ^{[1
,3
]}

Roosen, Jesse ^{[1
]}

van Kempen, Zoe L. E. ^{[4
]}

Killestein, Joep ^{[4
]}

Volkers, Adriaan G. ^{[5
]}

Boekel, Laura ^{[6
]}

Wolbink, Gerrit J. ^{[6
]}

van der Kooi, Anneke J. ^{[1
]}

Raaphorst, Joost ^{[1
]}

Lowenberg, Mark ^{[5
]}

Takkenberg, R. Bart ^{[5
]}

D'Haens, Geert R. A. M. ^{[5
]}

Spuls, Phyllis I. ^{[7
]}

Bekkenk, Marcel W. ^{[7
]}

Musters, Annelie H. ^{[7
]}

Post, Nicoline F. ^{[7
]}

Bosma, Angela L. ^{[7
]}

Hilhorst, Marc L. ^{[8
]}

Vegting, Yosta ^{[8
]}

Bemelman, Frederike J. ^{[8
]}

Voskuyl, Alexandre E. ^{[9
]}

Broens, Bo ^{[9
]}

Sanchez, Agner Parra ^{[9
,10
]}

van Els, Cecile A. C. M. ^{[11
,12
]}

de Wit, Jelle ^{[11
]}

Rutgers, Abraham ^{[13
]}

de Leeuw, Karina ^{[13
]}

Horvath, Barbara ^{[14
]}

Verschuuren, Jan J. G. M. ^{[15
]}

Ruiter, Annabel M. ^{[15
]}

van Ouwerkerk, Lotte ^{[16
]}

van der Woude, Diane ^{[16
]}

Allaart, Renee C. F. ^{[16
]}

Teng, Y. K. Onno ^{[17
]}

van Paassen, Pieter ^{[18
]}

Busch, Matthias H. ^{[18
]}

Jallah, Papay B. P. ^{[18
]}

Brusse, Esther ^{[19
]}

van Doorn, Pieter A. ^{[19
]}

Baars, Adaja E. ^{[19
]}

Hijnen, Dirk Jan ^{[20
]}

Schreurs, Corine R. G. ^{[20
]}

van der Pol, W. Ludo ^{[21
]}

Goedee, H. Stephan ^{[21
]}

Steenhuis, Maurice ^{[3
]}

Keijzer, Sofie ^{[3
]}

Keijser, Jim B. D. ^{[3
]}

机构：

[1] Univ Amsterdam, Dept Neurol & Neurophysiol, Amsterdam Neurosci, Amsterdam UMC, Amsterdam, Netherlands

[2] St Antonius Hosp, Dept Clin Neurophysiol, Nieuwegein, Netherlands

[3] Amsterdam UMC, Dept Immunopathol, Sanquin Res & Landsteiner Lab, Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Dept Neurol, Amsterdam UMC, Med Ctr, Amsterdam, Netherlands

[5] Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol & Hepatol, Amsterdam UMC, Amsterdam, Netherlands

[6] Reade, Amsterdam Rheumatol & Immunol Ctr, Dept Rheumatol, Amsterdam, Netherlands

[7] Univ Amsterdam, Acad Med Ctr, Dept Dermatol, Amsterdam UMC, Amsterdam, Netherlands

[8] Univ Amsterdam, Acad Med Ctr, Dept Internal Med, Sect Nephrol, Amsterdam, Netherlands

[9] Vrije Univ Amsterdam, Amsterdam Rheumatol & Immunol Ctr, Dept Rheumatol & Clin Immunol, Med Ctr, Amsterdam, Netherlands

[10] Univ Amsterdam, Amsterdam Rheumatol & Immunol Ctr, Dept Rheumatol & Clin Immunol, Amsterdam UMC, Amsterdam, Netherlands

[11] Natl Inst Publ Hlth & Environm RIVM, Ctr Infect Dis Control, Bilthoven, Netherlands

[12] Univ Utrecht, Fac Vet Med, Utrecht, Netherlands

[13] Univ Med Ctr Groningen, Dept Rheumatol & Clin Immunol, Groningen, Netherlands

[14] Univ Groningen, Univ Med Ctr Groningen, Ctr Blistering Dis, Dept Dermatol, Groningen, Netherlands

[15] Leiden Univ, Dept Neurol, Med Ctr, Leiden, Netherlands

[16] Leiden Univ, Dept Rheumatol, Med Ctr, Leiden, Netherlands

[17] Leiden Univ, Ctr Expertise Lupus Vasculitis & Complement Media, Dept Internal Med Nephrol Sect, Med Ctr, Leiden, Netherlands

[18] Maastricht Univ, Dept Nephrol & Clin Immunol, Med Ctr, Maastricht, Netherlands

[19] Univ Med Ctr, Dept Neurol, Erasmus MC, Rotterdam, Netherlands

[20] Univ Med Ctr, Dept Dermatol, Erasmus MC, Rotterdam, Netherlands

[21] UMC Utrecht, Dept Neurol & Neurosurg, Brain Ctr, Utrecht, Netherlands

[22] Univ Amsterdam, Swammerdam Inst Life Sci, Amsterdam, Netherlands

[23] Univ Amsterdam, Dept Pediat Immunol Rheumatol & Infect Dis, Amsterdam UMC, AMC, Amsterdam, Netherlands

来源：

JOURNAL OF AUTOIMMUNITY | 2023年 / 135卷

关键词：

SARS-CoV-2; COVID-19; Vaccination; Autoimmune disease; Disease activity; Flare;

D O I：

10.1016/j.jaut.2022.102984

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

For patients with immune-mediated inflammatory diseases (IMIDs), concerns exist about increased disease ac-tivity after vaccination. We aimed to assess changes in disease activity after SARS-CoV-2 vaccination in patients with IMIDs, and determine risk factors for increased disease activity. In this substudy of a prospective obser-vational cohort study (Target-to-B!), we included patients with IMIDs who received a SARS-CoV-2 vaccine. Patients reported changes in disease activity on a five-point Likert scale every 60 days for up to twelve months after first vaccination. In case of self-reported increased activity, hospital records were screened whether the treating physician reported increased activity, and for potential intensification of immunosuppressive (ISP) treatment. Mixed models were used to study determinants for self-reported increased disease activity. In total, 2111 patients were included for analysis after primary immunization (mean age 49.7 years [SD 13.7], 1329/ 2111 (63.0%) female), from which 1266 patients for analysis after first additional vaccination. Increased disease activity at 60 days after start of primary immunization was reported by 223/2111 (10.6%). In 96/223 (43.0%) the increase was confirmed by the treating physician and in 36/223 (16.1%) ISP treatment was intensified. Increased disease activity at seven to 60 days after additional vaccination, was reported by 139/1266 (11.0%). Vaccinations were not temporally associated with self-reported increased disease activity. Conversely, increased disease activity before first vaccination, neuromuscular disease, and multiple sclerosis were associated. Alto-gether, self-reported increased disease activity after vaccination against SARS-CoV-2 was recorded in a minority of patients and was generally mild. Moreover, multivariate analyses suggest that disease related factors, but not vaccinations are the major determinants for self-reported increased disease activity.

引用

页数：9

共 50 条

[21] The emergence of rheumatic immune-mediated inflammatory disease manifestations following SARS-CoV-2 vaccination
Nune, Arvind
Sapkota, Hem
Iyengar, Karthikeyan
INDIAN JOURNAL OF RHEUMATOLOGY, 2022, 17 (02) : 214 - 215
[22] Humoral immune response after SARS-CoV-2 vaccination in patients with immune-mediated inflammatory diseases treated with immunosuppressive therapy - a Target to B! study
Volkers, A.
Wieske, L.
van Dam, K.
Steenhuis, M.
Stalman, E.
Kummer, L.
van Kempen, Z.
Killestein, J.
Tas, S.
Boekel, L.
Wolbink, G.
Takkenberg, B.
Spuls, P.
Bosma, A.
Rutgers, B.
Verschuuren, J.
van Ouwerkerk, L.
van der Woude, D.
van Paassen, P.
Busch, M.
Brusse, E.
Hijnen, D.
ten Brinke, A.
Verstegen, N.
D'Haens, G.
van Ham, M.
Kuijpers, T.
Rispens, T.
Lowenberg, M.
Eftimov, F.
JOURNAL OF CROHNS & COLITIS, 2022, 16 : I079 - I079
[23] Breakthrough infections with the SARS-CoV-2 omicron (B.1.1.529) variant in patients with immune-mediated inflammatory diseases
Stalman, Eileen W.
Wieske, Luuk
van Dam, Koos P. J.
Kummer, Laura Y.
van Kempen, Zoe L. E.
Killestein, Joep
Volkers, Adriaan G.
Tas, Sander W.
Boekel, Laura
Wolbink, Gertjan J.
Van der Kooi, Anneke J.
Raaphorst, Joost
Lowenberg, Mark
Takkenberg, R. Bart
D'Haens, Geert R. A. M.
Spuls, Phyllis, I
Bekkenk, Marcel W.
Musters, Annelie H.
Post, Nicoline F.
Bosma, Angela L.
Hilhorst, Marc L.
Vegting, Yosta
Bemelman, Frederique J.
Voskuyl, Alexandre E.
Broens, Bo
Parra Sanchez, Agner
van Els, Cecile A. C. M.
De Wit, Jelle
Rutgers, Abraham
de Leeuw, Karina
Horvath, Barbara
Verschuuren, Jan J. G. M.
Ruiter, Annabel M.
van Ouwerkerk, Lotte
van der Woude, Diane
Allaart, C. F.
Teng, Onno Y. K.
van Paassen, Pieter
Busch, Matthias H.
Jallah, Papay B. P.
Brusse, Esther
van Doorn, Pieter A.
Baars, Adaja Elisabeth
Hijnen, Dirk Jan
Schreurs, Corine R. G.
Van der Pol, W. Ludo
Goedee, H. Stephan
Steenhuis, Maurice
Keijzer, Sofie
Keijser, Jim B. D.
ANNALS OF THE RHEUMATIC DISEASES, 2022, 81 (12) : 1757 - 1766
[24] Humoral and cellular responses to spike of 8 SARS-CoV-2 variant in vaccinated patients with immune-mediated inflammatory diseases
Petrone, Linda
Picchianti-Diamanti, Andrea
Sebastiani, Gian Domenico
Aiello, Alessandra
Lagana, Bruno
Cuzzi, Gilda
Vanini, Valentina
Gualano, Gina
Grifoni, Alba
Ferraioli, Mario
Castilletti, Concetta
Meschi, Silvia
Vaia, Francesco
Nicastri, Emanuele
Sette, Alessandro
Goletti, Delia
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2022, 121 : 24 - 30
[25] Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion
Simon, David
Tascilar, Koray
Kroenke, Gerhard
Kleyer, Arnd
Zaiss, Mario M.
Heppt, Franz
Meder, Christine
Atreya, Raja
Klenske, Entcho
Dietrich, Peter
Abdullah, Abdullah
Kliem, Thorsten
Corte, Giulia
Morf, Harriet
Leppkes, Moritz
Kremer, Andreas E.
Ramming, Andreas
Pachowsky, Milena
Schuch, Florian
Ronneberger, Monika
Kleinert, Stefan
Maier, Clara
Hueber, Axel J.
Manger, Karin
Manger, Bernhard
Berking, Carola
Tenbusch, Matthias
Ueberla, Klaus
Sticherling, Michael
Neurath, Markus F.
Schett, Georg
NATURE COMMUNICATIONS, 2020, 11 (01)
[26] Seroprevalence of SARS-CoV-2 antibodies in patients with immune-mediated inflammatory diseases treated with biological and synthetic targeted therapies
Romero-Bogado, Liz
Steiner, Martina
Vasallo, Israel John Thuissard
Andreu-Vazquez, Cristina
Cobo-Ibanez, Tatiana
Gomez, Alejandro Gomez
Paredes-Romero, Maria Beatriz
Esteban-Vazquez, Ana
Mendez, Laura Cebrian
De La Mano, Maria Angeles Matias
Garcia-Yubero, Cristina
Hernandez, Alicia Martinez
Ortega, Mar Esteban
Marcos, Noemi Mancenido
Pajares, Ramon
Alba, Concepcion Esteban
Santos, Raquel Guillen
Marcos, Teresa Navio
Munoz-Fernandez, Santiago
REVISTA CHILENA DE INFECTOLOGIA, 2023, 40 (06): : 618 - 625
[27] Impact of the First SARS-CoV-2 Lockdown on Adherence to Biological Treatment in Patients with Immune-Mediated Inflammatory Diseases in the Netherlands
van der Groef, Romy
de Jong, Pascal H. P.
Hijnen, Dirk Jan
van der Woude, Christien J.
van Laar, Jan A. M.
van der Kuy, P. Hugo M.
Brugma, Jan-Dietert
Pasma, Annelieke
PATIENT PREFERENCE AND ADHERENCE, 2023, 17 : 167 - 174
[28] Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion
David Simon
Koray Tascilar
Gerhard Krönke
Arnd Kleyer
Mario M. Zaiss
Franz Heppt
Christine Meder
Raja Atreya
Entcho Klenske
Peter Dietrich
Abdullah Abdullah
Thorsten Kliem
Giulia Corte
Harriet Morf
Moritz Leppkes
Andreas E. Kremer
Andreas Ramming
Milena Pachowsky
Florian Schuch
Monika Ronneberger
Stefan Kleinert
Clara Maier
Axel J. Hueber
Karin Manger
Bernhard Manger
Carola Berking
Matthias Tenbusch
Klaus Überla
Michael Sticherling
Markus F. Neurath
Georg Schett
Nature Communications, 11
[29] Immune-mediated inflammatory diseases after anti-SARS-CoV-2 vaccines: new diagnoses and disease flares
Carubbi, Francesco
Alunno, Alessia
Santilli, Jessica
Natali, Laura
Mancini, Bernardina
Di Gregorio, Nicoletta
Del Pinto, Rita
Viscido, Angelo
Grassi, Davide
Ferri, Claudio
RMD OPEN, 2022, 8 (02):
[30] The Safety Profile of SARS-CoV-2 Vaccines Among Patients with Immune-Mediated Rheumatic Diseases
Gomez-Puerta, Jose A.
Sapena, Nuria
Sarmiento-Monroy, Juan C.
Belen Azuaga, Ana
Ruiz-Esquide, Virginia
Frade-Sosa, Beatriz
Bassas, Marta
Morla, Rosa
Ponce, Andres
Canete, Juan D.
Ramirez, Julio
Villella, Anna
Trilla, Antoni
Sanmarti, Raimon
ARTHRITIS & RHEUMATOLOGY, 2021, 73 : 223 - 225

← 1 2 3 4 5 →