A new β-class milbemycin derivative from a mutant of genetically engineered strain Streptomyces avermitilis AVE-H39

被引：2

作者：

Qi, Huan ^{[1
]}

Zhang, Cheng-Hong ^{[1
]}

Zhang, Shao-Yong ^{[1
]}

Song, Wen-Shuai ^{[2
]}

Xiang, Wen-Sheng ^{[2
]}

Zhang, Li-Qin ^{[1
]}

Wang, Ji-Dong ^{[1
]}

机构：

[1] Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang P, Huzhou, Peoples R China

[2] Northeast Agr Univ, Sch Life Sci, Life Sci & Biotechnol Res Ctr, Harbin, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 07期

关键词：

Streptomyces avermitilis AVE-H39; NTG-induced mutation; beta-class milbemycin; nematocidal activity; IVERMECTIN; RESISTANCE; AVERMECTIN; MUTATION;

D O I：

10.1080/14786419.2021.1986496

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new beta-class milbemycin, 13 alpha-hydroxy milbemycin beta(6) (1), was isolated from the fermentation broth of a mutant of genetically engineered strain Streptomyces avermitilis AVE-H39. Its structure and absolute configuration were elucidated by extensive spectroscopic methods and confirmed by single crystal X-ray diffraction. [GRAPHICS]

引用

页码：1212 / 1216

页数：5

共 22 条

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[20] Isolation and Characterization of New 16-Membered Macrolides from the aveA3 Gene Replacement Mutant Strain Streptomyces avermitilis TM24 with Acaricidal and Nematicidal Activities
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