A new β-class milbemycin derivative from a mutant of genetically engineered strain Streptomyces avermitilis AVE-H39

被引：2
|
作者：
Qi, Huan [1 ]
Zhang, Cheng-Hong [1 ]
Zhang, Shao-Yong [1 ]
Song, Wen-Shuai [2 ]
Xiang, Wen-Sheng [2 ]
Zhang, Li-Qin [1 ]
Wang, Ji-Dong [1 ]
机构：
[1] Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang P, Huzhou, Peoples R China
[2] Northeast Agr Univ, Sch Life Sci, Life Sci & Biotechnol Res Ctr, Harbin, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 07期
关键词：
Streptomyces avermitilis AVE-H39; NTG-induced mutation; beta-class milbemycin; nematocidal activity; IVERMECTIN; RESISTANCE; AVERMECTIN; MUTATION;
D O I：
10.1080/14786419.2021.1986496
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new beta-class milbemycin, 13 alpha-hydroxy milbemycin beta(6) (1), was isolated from the fermentation broth of a mutant of genetically engineered strain Streptomyces avermitilis AVE-H39. Its structure and absolute configuration were elucidated by extensive spectroscopic methods and confirmed by single crystal X-ray diffraction. [GRAPHICS]
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收藏
页码：1212 / 1216
页数：5
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