Multisite Thrombosis in a Patient with Paroxysmal Nocturnal Hemoglobinuria

被引：2

作者：

Beckmann, Lennart

Faizy, Tobias D.

Flottmann, Fabian

Fiehler, Jens ^{[2
]}

Bokemeyer, Carsten ^{[1
]}

Well, Lennart ^{[3
]}

Beitzen-Heineke, Antonia

Langer, Florian ^{[1
]}

机构：

[1] Univ Klinikum Eppendorf, Zentrum Onkol, Med Klin 2, Martinistr 52, D-20246 Hamburg, Germany

[2] Univ Klinikum Eppendorf, Zentrum Radiol & Endoskopie, Klin & Poliklin Neuroradiol Diagnost & Intervent, Hamburg, Germany

[3] Univ Klinikum Eppendorf, Zentrum Radiol & Endoskopie, Klin & Poliklin Diagnost & Intervent Radiol & Nukl, Hamburg, Germany

来源：

HAMOSTASEOLOGIE | 2024年

关键词：

D O I：

10.1055/a-2231-5277

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Paroxysmal nocturnal hemoglobinuria (PNH) is an extremely rare bone marrow disorder caused by acquired mutations in the phosphatidylinositol glycan class A gene, which lead to a partial or total loss of the cellular complement regulators CD55 and CD59. 1 In addition to complement-mediated hemolysis and cytopenia, venous and arterial thromboses at multiple and/or unusual sites are a common complication and occur in up to 44% of patients in historic PNH cohorts. (1 2)

引用

页数：4

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