A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism

被引：14
|
作者：
Thind, Mehakpreet K. [1 ,2 ,3 ]
Uhlig, Holm H. [4 ,5 ,6 ]
Glogauer, Michael [7 ,8 ]
Palaniyar, Nades [2 ,9 ,10 ]
Bourdon, Celine [2 ,3 ]
Gwela, Agnes [3 ,11 ]
Lancioni, Christina L. [3 ,12 ]
Berkley, James A. [3 ,11 ,13 ]
Bandsma, Robert H. J. [1 ,2 ,3 ,14 ,15 ]
Farooqui, Amber [2 ,3 ,16 ]
机构：
[1] Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON, Canada
[2] Hosp Sick Children, Translat Med Program, Toronto, ON, Canada
[3] Childhood Acute Illness & Nutr Network CHAIN, Nairobi, Kenya
[4] Univ Oxford, John Radcliffe Hosp, Translat Gastroenterol Unit, Expt Med, Oxford, England
[5] Univ Oxford, Dept Paediat, Oxford, England
[6] Univ Oxford, Biomed Res Ctr, Oxford, England
[7] Univ Toronto, Fac Dent, Toronto, ON, Canada
[8] Univ Hlth Network, Princess Margaret Canc Ctr, Dept Dent Oncol & Maxillofacial Prosthet, Toronto, ON, Canada
[9] Univ Toronto, Fac Med, Lab Med & Pathobiol, Toronto, ON, Canada
[10] Univ Toronto, Inst Med Sci, Fac Med, Toronto, ON, Canada
[11] Kenya Med Res Inst KEMRI, Ctr Geog Med Res, Wellcome Trust Res Programme, Kilifi, Kenya
[12] Oregon Hlth & Sci Univ, Dept Pediat, Portland, OR USA
[13] Univ Oxford, Ctr Trop Med & Global Hlth, Oxford, England
[14] Univ Groningen, Univ Med Ctr Groningen, Ctr Liver Digest & Metab Dis, Lab Pediat, Groningen, Netherlands
[15] Hosp Sick Children, Div Gastroenterol Hepatol & Nutr, Toronto, ON, Canada
[16] Omega Labs Inc, Mississauga, ON, Canada
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 14卷
基金：
加拿大健康研究院;
关键词：
metabolic reprogramming; neutrophil differentiation; glycolysis; immune mediated diseases; autophagy; mitochondrial respiration; HEMATOPOIETIC STEM-CELLS; PENTOSE-PHOSPHATE PATHWAY; FATTY-ACID OXIDATION; EXTRACELLULAR TRAPS; BONE-MARROW; C/EBP-BETA; MYELOID DIFFERENTIATION; PROGENITOR CELLS; HOST-DEFENSE; MAST-CELLS;
D O I：
10.3389/fimmu.2023.1334205
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Neutrophils are the most abundant innate immune cells. Multiple mechanisms allow them to engage a wide range of metabolic pathways for biosynthesis and bioenergetics for mediating biological processes such as development in the bone marrow and antimicrobial activity such as ROS production and NET formation, inflammation and tissue repair. We first discuss recent work on neutrophil development and functions and the metabolic processes to regulate granulopoiesis, neutrophil migration and trafficking as well as effector functions. We then discuss metabolic syndromes with impaired neutrophil functions that are influenced by genetic and environmental factors of nutrient availability and usage. Here, we particularly focus on the role of specific macronutrients, such as glucose, fatty acids, and protein, as well as micronutrients such as vitamin B3, in regulating neutrophil biology and how this regulation impacts host health. A special section of this review primarily discusses that the ways nutrient deficiencies could impact neutrophil biology and increase infection susceptibility. We emphasize biochemical approaches to explore neutrophil metabolism in relation to development and functions. Lastly, we discuss opportunities and challenges to neutrophil-centered therapeutic approaches in immune-driven diseases and highlight unanswered questions to guide future discoveries.
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页数：22
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