Effects of carotenoids on mitochondrial dysfunction

被引:4
|
作者
Ademowo, Opeyemi Stella [1 ]
Oyebode, Olubukola [1 ]
Edward, Roshita [1 ]
Conway, Myra E. [1 ]
Griffiths, Helen R. [2 ]
Dias, Irundika H. K. [3 ]
机构
[1] Univ Derby, Sch Sci, Biomed & Clin Sci Res, Derby, England
[2] Swansea Univ, Fac Med Hlth & Life Sci, Swansea, Wales
[3] Aston Univ, Coll Hlth & Life Sci, Aston Med Sch, Birmingham, England
关键词
OXIDATIVE STRESS; COMPLEXES; DISEASE;
D O I
10.1042/BST20230193
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Oxidative stress, an imbalance between pro-oxidant and antioxidant status, favouring the pro-oxidant state is a result of increased production of reactive oxygen species (ROS) or inadequate antioxidant protection. ROS are produced through several mechanisms in cells including during mitochondrial oxidative phosphorylation. Increased mitochondrialderived ROS are associated with mitochondrial dysfunction, an early event in age-related diseases such as Alzheimer's diseases (ADs) and in metabolic disorders including diabetes. AD post-mortem investigations of affected brain regions have shown the accumulation of oxidative damage to macromolecules, and oxidative stress has been considered an important contributor to disease pathology. An increase in oxidative stress, which leads to increased levels of superoxide, hydrogen peroxide and other ROS in a potentially vicious cycle is both causative and a consequence of mitochondrial dysfunction. Mitochondrial dysfunction may be ameliorated by molecules with antioxidant capacities that accumulate in mitochondria such as carotenoids. However, the role of carotenoids in mitigating mitochondrial dysfunction is not fully understood. A better understanding of the role of antioxidants in mitochondrial function is a promising lead towards the development of novel and effective treatment strategies for age-related diseases. This review evaluates and summarises some of the latest developments and insights into the effects of carotenoids on mitochondrial dysfunction with a focus on the antioxidant properties of carotenoids. The mitochondria-protective role of carotenoids may be key in therapeutic strategies and targeting the mitochondria ROS is emerging in drug development for agerelated diseases.
引用
收藏
页码:65 / 74
页数:10
相关论文
共 50 条
  • [41] Mitochondrial dysfunction in cystinosis
    Trauner, D. A.
    Haas, R. H.
    Phillips, P. S.
    Powell, H.
    Hansel, L.
    Barshop, B. A.
    Le, T.
    Gangoiti, J.
    Romine, K.
    Panyard, J.
    Spilkin, A.
    ANNALS OF NEUROLOGY, 2008, 64 : S110 - S110
  • [42] Mitochondrial dysfunction and aging
    Melov, S
    GERONTOLOGIST, 2001, 41 : 65 - 65
  • [43] Mitochondrial Dysfunction in Depression
    Bansal, Yashika
    Kuhad, Anurag
    CURRENT NEUROPHARMACOLOGY, 2016, 14 (06) : 610 - 618
  • [44] Mitochondrial dysfunction in schizophrenia
    Huffaker, S
    Ryan, M
    Bahn, S
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2004, 7 : S80 - S80
  • [45] Mitochondrial dysfunction in cancer
    Boland, Michelle L.
    Chourasia, Aparajita H.
    Macleod, Kay F.
    FRONTIERS IN ONCOLOGY, 2013, 3
  • [46] Mitochondrial Dysfunction and Glaucoma
    Kong, George Y. X.
    Van Bergen, Nicole J.
    Trounce, Ian A.
    Crowston, Jonathan G.
    JOURNAL OF GLAUCOMA, 2009, 18 (02) : 93 - 100
  • [47] Mitochondrial dysfunction in epilepsy
    Folbergrova, Jaroslava
    Kunz, Wolfram S.
    MITOCHONDRION, 2012, 12 (01) : 35 - 40
  • [48] Mitochondrial dysfunction in reproduction
    Jansen, RPS
    Burton, GJ
    MITOCHONDRION, 2004, 4 (5-6) : 577 - 600
  • [49] Mitochondrial Dysfunction in Autism
    Giulivi, Cecilia
    Zhang, Yi-Fan
    Omanska-Klusek, Alicja
    Ross-Inta, Catherine
    Wong, Sarah
    Hertz-Picciotto, Irva
    Tassone, Flora
    Pessah, Isaac N.
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 304 (21): : 2389 - 2396
  • [50] Mitochondrial dysfunction in sepsis
    Singer, M
    Brealey, D
    MITOCHONDRIA AND CELL DEATH, 1999, 66 : 149 - 166