Isolation and structure determination of a new analog of polycavernosides from marine Okeania sp. cyanobacterium

被引：4

作者：

Umeda, Kairi ^{[1
]}

Kurisawa, Naoaki ^{[1
]}

Jeelani, Ghulam ^{[2
]}

Nozaki, Tomoyoshi ^{[2
]}

Suenaga, Kiyotake ^{[1
]}

Iwasaki, Arihiro ^{[3
]}

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Chem, 3-14-1 Hiyoshi,Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Biomed Chem, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1130033, Japan

[3] Chuo Univ, Fac Sci & Engn, Dept Appl Chem, 1-13-27 Kasuga,Bunkyo Ku, Tokyo 1128551, Japan

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 20卷

关键词：

macrolide glycoside; marine cyanobacterium; marine natural products; polycavernosides; terminal alkyne; RED ALGA; LETHAL TOXIN;

D O I：

10.3762/bjoc.20.57

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polycavernoside E (1), a new polycavernoside analog, was isolated from a marine Okeania sp. cyanobacterium. The relative configuration was elucidated primarily by analyzing the two dimensional nuclear magnetism resonance (2D NMR) data. The absolute configuration was clarified by comparing the electronic circular dichroism (ECD) data of 1 with those of known analogs. Polycavernoside E (1) exhibited moderate antitrypanosomal activity against Trypanosoma brucei rhodesiense. Furthermore, the isolation of polycavernoside E (1) from marine cyanobacteria provides additional evidence that marine cyanobacteria, and not red algae, are responsible for the biosynthesis of polycavernosides.

引用

页码：645 / 652

页数：8

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