Functions of mucosal associated invariant T cells in eye diseases

被引：0
|
作者：
Fukui, Chihiro [1 ]
Yamana, Satoshi [1 ]
Xue, Yanqi [1 ]
Shirane, Mariko [1 ]
Tsutsui, Hiroki [1 ]
Asahara, Kenichiro [1 ]
Yoshitomi, Keiko [1 ]
Ito, Takako [1 ]
Lestari, Tantri [1 ]
Hasegawa, Eiichi [1 ]
Yawata, Nobuyo [2 ]
Takeda, Atsunobu [1 ]
Sonoda, Koh-Hei [1 ]
Shibata, Kensuke [2 ,3 ,4 ]
机构：
[1] Kyushu Univ, Grad Sch Med Sci, Dept Ophthalmol, Fukuoka, Japan
[2] Kyushu Univ, Grad Sch Med Sci, Dept Ocular Pathol & Imaging Sci, Fukuoka, Japan
[3] Yamaguchi Univ, Grad Sch Med, Dept Microbiol & Immunol, Ube, Japan
[4] Osaka Univ, Res Inst Microbial Dis, Dept Mol Immunol, Suita, Japan
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
基金：
日本学术振兴会;
关键词：
eye; autoimmune disease; metabolite; T cells; immunotherapy; ACUTE ANTERIOR UVEITIS; MAIT CELLS; OCULAR AUTOIMMUNITY; ACTIVATION; EPIDEMIOLOGY; INDUCTION; TOLERANCE; MECHANISM; SELECTION; DRIVE;
D O I：
10.3389/fimmu.2024.1341180
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mucosal-associated invariant T (MAIT) cells are a unique subset of T cells that recognizes metabolites derived from the vitamin B2 biosynthetic pathway. Since the identification of cognate antigens for MAIT cells, knowledge of the functions of MAIT cells in cancer, autoimmunity, and infectious diseases has been rapidly expanding. Recently, MAIT cells have been found to contribute to visual protection against autoimmunity in the eye. The protective functions of MAIT cells are induced by T-cell receptor (TCR)-mediated activation. However, the underlying mechanisms remain unclear. Thus, this mini-review aims to discuss our findings and the complexity of MAIT cell-mediated immune regulation in the eye.
引用
收藏
页数：7
相关论文
共 50 条
  • [21] Mucosal-associated invariant T cells for cancer immunotherapy
    Li, Yan-Ruide
    Zhou, Kuangyi
    Wilson, Matthew
    Kramer, Adam
    Zhu, Yichen
    Dawson, Niels
    Yang, Lili
    MOLECULAR THERAPY, 2023, 31 (03) : 631 - 646
  • [22] The role of mucosal associated invariant T cells in antimicrobial immunity
    Napier, Ruth J.
    Adams, Erin J.
    Gold, Marielle C.
    Lewinsohn, David M.
    FRONTIERS IN IMMUNOLOGY, 2015, 6
  • [23] Mucosal Associated Invariant T Cells in Giant Cell Arteritis
    Ghesquiere, Thibault
    Ciudad, Marion
    Greigert, Helene
    Gerard, Claire
    Cladiere, Claudie
    Thebaut, Marine
    Guilhem, Alexandre
    Leguy-Seguin, Vanessa
    Berthier, Sabine
    Falvo, Nicolas
    Nicolas, Barbara
    Maillet, Thibault
    Devilliers, Herve
    Bielefeld, Philip
    Vernier, Nathalie
    Maurier, Francois
    Ornetti, Paul
    Quipourt, Valerie
    Gabrielle, Pierre-Henry
    Creuzot-Garcher, Catherine
    Martin, Laurent
    Audia, Sylvain
    Bonnotte, Bernard
    Samson, Maxime
    ARTHRITIS & RHEUMATOLOGY, 2019, 71
  • [24] Mucosal-Associated Invariant T Cells in Regenerative Medicine
    Wakao, Hiroshi
    Sugimoto, Chie
    Kimura, Shinzo
    Wakao, Rika
    FRONTIERS IN IMMUNOLOGY, 2017, 8
  • [25] Persistent deficiency of mucosal associated invariant T cells in dermatomyositis
    Cassius, C.
    Branchtein, M.
    Battistella, M.
    Lepelletier, C.
    De Masson, A.
    Bensussan, A.
    Bagot, M.
    Le Buanec, H.
    Bouaziz, J.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2019, 139 (09) : S222 - S222
  • [26] Antimicrobial activity of mucosal-associated invariant T cells
    Le Bourhis, Lionel
    Martin, Emmanuel
    Peguillet, Isabelle
    Guihot, Amelie
    Froux, Nathalie
    Core, Maxime
    Levy, Eva
    Dusseaux, Mathilde
    Meyssonnier, Vanina
    Premel, Virginie
    Ngo, Charlotte
    Riteau, Beatrice
    Duban, Livine
    Robert, Delphine
    Rottman, Martin
    Soudais, Claire
    Lantz, Olivier
    NATURE IMMUNOLOGY, 2010, 11 (08) : 701 - U66
  • [27] Mucosal associated invariant T cells and the immune response to infection
    Gold, Marielle C.
    Lewinsohn, David M.
    MICROBES AND INFECTION, 2011, 13 (8-9) : 742 - 748
  • [28] Invariant Natural Killer T and Mucosal-Associated Invariant T Cells in Asthmatic Patients
    Lezmi, Guillaume
    Leite-de-Moraes, Maria
    FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [29] Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease
    Hinks, Timothy S. C.
    IMMUNOLOGY, 2016, 148 (01) : 1 - 12
  • [30] Mucosal-associated invariant T cells in infectious diseases of respiratory system: recent advancements and applications
    Xue Lin
    Ye Wang
    Yanqi He
    Journal of Inflammation, 21
12345