Functions of mucosal associated invariant T cells in eye diseases

被引：0

作者：

Fukui, Chihiro ^{[1
]}

Yamana, Satoshi ^{[1
]}

Xue, Yanqi ^{[1
]}

Shirane, Mariko ^{[1
]}

Tsutsui, Hiroki ^{[1
]}

Asahara, Kenichiro ^{[1
]}

Yoshitomi, Keiko ^{[1
]}

Ito, Takako ^{[1
]}

Lestari, Tantri ^{[1
]}

Hasegawa, Eiichi ^{[1
]}

Yawata, Nobuyo ^{[2
]}

Takeda, Atsunobu ^{[1
]}

Sonoda, Koh-Hei ^{[1
]}

Shibata, Kensuke ^{[2
,3
,4
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Ophthalmol, Fukuoka, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Ocular Pathol & Imaging Sci, Fukuoka, Japan

[3] Yamaguchi Univ, Grad Sch Med, Dept Microbiol & Immunol, Ube, Japan

[4] Osaka Univ, Res Inst Microbial Dis, Dept Mol Immunol, Suita, Japan

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

基金：

日本学术振兴会;

关键词：

eye; autoimmune disease; metabolite; T cells; immunotherapy; ACUTE ANTERIOR UVEITIS; MAIT CELLS; OCULAR AUTOIMMUNITY; ACTIVATION; EPIDEMIOLOGY; INDUCTION; TOLERANCE; MECHANISM; SELECTION; DRIVE;

D O I：

10.3389/fimmu.2024.1341180

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mucosal-associated invariant T (MAIT) cells are a unique subset of T cells that recognizes metabolites derived from the vitamin B2 biosynthetic pathway. Since the identification of cognate antigens for MAIT cells, knowledge of the functions of MAIT cells in cancer, autoimmunity, and infectious diseases has been rapidly expanding. Recently, MAIT cells have been found to contribute to visual protection against autoimmunity in the eye. The protective functions of MAIT cells are induced by T-cell receptor (TCR)-mediated activation. However, the underlying mechanisms remain unclear. Thus, this mini-review aims to discuss our findings and the complexity of MAIT cell-mediated immune regulation in the eye.

引用

页数：7

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