Immune response plays a role in Mycoplasma pneumoniae pneumonia

被引：26

作者：

Zhu, Yifan ^{[1
]}

Luo, Yingying ^{[1
]}

Li, Ling ^{[2
]}

Jiang, Xinyi ^{[1
]}

Du, Yi ^{[1
]}

Wang, Jing ^{[1
]}

Li, Huilin ^{[1
]}

Gu, Haiyan ^{[1
]}

Li, Daiying ^{[3
]}

Tang, Heng ^{[1
]}

Qin, Houbing ^{[1
]}

Xu, Changdi ^{[1
]}

Liu, Yan ^{[1
]}

Zhao, Deyu ^{[1
]}

Guo, Yun ^{[2
]}

Liu, Feng ^{[1
]}

机构：

[1] Nanjing Med Univ, Childrens Hosp, Dept Resp Med, Nanjing, Peoples R China

[2] Nanjing Med Univ, Affiliated Wuxi Childrens Hosp, Dept Resp Med, Wuxi, Peoples R China

[3] Vis Med Ctr Infect Dis, Guangzhou, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

基金：

中国国家自然科学基金;

关键词：

Mycoplasma pneumoniae pneumonia; microbiome; transcriptome; the immune response; Mycoplasma pneumoniae; NEUTROPHILS; EXPRESSION; RECEPTORS; CHILDREN;

D O I：

10.3389/fimmu.2023.1189647

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IntroductionMycoplasma pneumoniae (MP) is a major pathogen of community-acquired pneumonia in children. However, the specific pathogenesis of the progression of Mycoplasma pneumoniae pneumonia (MPP) is unclear. We aimed to reveal the landscape of microbiota and the host immune response in MPP. MethodsThis self-controlled study analyzed the microbiome and transcriptome of bronchoalveolar lavage fluid (BALF) from the severe side (SD) and opposite side (OD) of 41 children with MPP from January to December 2021 and revealed the differences of the peripheral blood neutrophil function among children with mild MPP, severe MPP, and healthy children through transcriptome sequencing. ResultsThe MP load or the pulmonary microbiota had no significant difference between the SD group and OD group, and the deterioration of MPP was related to the immune response, especially the intrinsic immune response. DiscussionThe immune response plays a role in MPP, which may inform treatment strategies for MPP.

引用

页数：11

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