A new hydrocyanine probe for imaging reactive oxygen species in the mitochondria of live cells

被引：4
|
作者：
Ying, Andy [1 ]
Ying, Laiqiang [2 ]
机构：
[1] Montgomery Blair High Sch, 51 Univ Blvd E, Silver Spring, MD 20901 USA
[2] ABP Biosci, 405 E Gude Dr, Rockville, MD 20850 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2023年 / 87卷
关键词：
Hydrocyanine; Fluorescence; Reactive oxygen species; Mitochondria; Cell imaging; HYDROGEN-PEROXIDE; FLUORESCENT;
D O I：
10.1016/j.bmcl.2023.129262
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new hydrocyanine probe containing a ROS-responsive element and a mitochondrial-targeting moiety, as well as a thiol-reactive chloromethyl group, has been designed for imaging reactive oxygen species (ROS) in the mitochondria of live cells. This hydrocyanine probe is cell-permeable, selectively targets mitochondria and responds to superoxide and hydroxyl radical, and can be used for detection of ROS production in the mitochondria of live cells caused by an oxidative stress.
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页数：3
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