Modeling the Landscape of Histone-Mutant Pediatric High-Grade Gliomas: A Study in Partner Alterations

被引：1

作者：

Lubanszky, Evan ^{[1
,2
]}

Hawkins, Cynthia ^{[1
,2
,3
,4
]}

机构：

[1] Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, Toronto, ON, Canada

[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[3] Hosp Sick Children, Div Pathol, Toronto, ON, Canada

[4] Univ Toronto, Hosp Sick Children, Arthur & Sonia Labatt Brain Res Ctr, Dept Paediat Lab Med, 555 Univ Ave, Toronto, ON M5G 1X8, Canada

来源：

CANCER DISCOVERY | 2023年 / 13卷 / 07期

关键词：

D O I：

10.1158/2159-8290.CD-23-0495

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pediatric high-grade gliomas represent a group of deadly, heterogeneous tumors, often driven by histone mutations and the accumulation of clonal mutations, correlating with different tumor types, locations, and age of onset. In this study, McNicholas and colleagues present 16 in vivo models of histone-driven gliomas to investigate subtype-specific tumor biology and treatment options.

引用

页码：1516 / 1517

页数：2

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