Reactivity of a,a-Dibromo Derivatives of o/p-Hydroxyacetophenones: An Efficient Synthesis of Some 2-Substituted 4-(4-Hydroxyphenyl)- and 4-(2-Hydroxyphenyl) thiazoles

The focus ofthe present work is to explore the reactivity ofa,a-dibromo derivatives ofo/p-hydroxyacetophenones for N and S containing nucleophiles, namely, thioamides and thioureas with the hope of developing an efficient synthesis of thiazole derivatives. The genesis of the study is to ascertain the effect of the ring-hydroxyl group on the course of the reaction. The study offers an efficient synthesis of two series of thiazoles, namely, 2-substituted 4-(4-hydroxyphenyl) thiazoles and 2-substituted 4-(2-hydroxyphenyl)thiazoles.