Methylenetetrahydrofolate Reductase Gene Polymorphism as a Risk Factor for Coronary Artery Disease

被引：0
|
作者：
Sowndarya, K. [1 ]
Manjrekar, Poornima A. [1 ]
Shenoy, Ramya [2 ]
Hegde, Anupama [1 ]
机构：
[1] Manipal Acad Higher Educ, Kasturba Med Coll Mangalore, Dept Biochem, Manipal 575004, Karnataka, India
[2] Manipal Acad Higher Educ, Manipal Coll Dent Sci Mangalore, Dept Publ Hlth Dent, Manipal, Karnataka, India
来源：
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY | 2023年 / 40卷 / 1期
关键词：
Coronary artery disease; Homocysteine; MTHFR; SNP; HOMOCYSTEINE LEVELS; C677T POLYMORPHISM; MTHFR; HEALTHY; IMPACT; POPULATION; CAD;
D O I：
10.1007/s12291-023-01162-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hyperhomocysteinemia (HHcy) is one of the factors contributing to the pathogenesis of coronary artery disease (CAD). Besides nutritional deficiency disorders, genetic polymorphism predominantly related to point mutation in the gene coding for Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the metabolism methionine-homocysteine (Hcy) has been implicated in HHcy. PubMed survey related to MTHFR gene polymorphism in CAD retrieved 143 articles from which 20 were selected in which MTHFR gene polymorphism and Hcy were estimated. The selected studies had estimated either MTHFRC677T or A1298C or both. All the studies detected presence of MTHFRC677T in CAD. Hcy levels were found to range from normal to HHcy with debatable association to CAD.
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页码：25 / 31
页数：7
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