Methylenetetrahydrofolate Reductase Gene Polymorphism as a Risk Factor for Coronary Artery Disease

被引：0

作者：

Sowndarya, K. ^{[1
]}

Manjrekar, Poornima A. ^{[1
]}

Shenoy, Ramya ^{[2
]}

Hegde, Anupama ^{[1
]}

机构：

[1] Manipal Acad Higher Educ, Kasturba Med Coll Mangalore, Dept Biochem, Manipal 575004, Karnataka, India

[2] Manipal Acad Higher Educ, Manipal Coll Dent Sci Mangalore, Dept Publ Hlth Dent, Manipal, Karnataka, India

来源：

INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY | 2023年 / 40卷 / 1期

关键词：

Coronary artery disease; Homocysteine; MTHFR; SNP; HOMOCYSTEINE LEVELS; C677T POLYMORPHISM; MTHFR; HEALTHY; IMPACT; POPULATION; CAD;

D O I：

10.1007/s12291-023-01162-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hyperhomocysteinemia (HHcy) is one of the factors contributing to the pathogenesis of coronary artery disease (CAD). Besides nutritional deficiency disorders, genetic polymorphism predominantly related to point mutation in the gene coding for Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the metabolism methionine-homocysteine (Hcy) has been implicated in HHcy. PubMed survey related to MTHFR gene polymorphism in CAD retrieved 143 articles from which 20 were selected in which MTHFR gene polymorphism and Hcy were estimated. The selected studies had estimated either MTHFRC677T or A1298C or both. All the studies detected presence of MTHFRC677T in CAD. Hcy levels were found to range from normal to HHcy with debatable association to CAD.

引用

页码：25 / 31

页数：7

共 50 条

[1] The methylenetetrahydrofolate reductase gene polymorphism in Koreans with coronary artery disease
Kim, CH
Hwang, KY
Choi, TM
Shin, WY
Hong, SY
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2001, 78 (01) : 13 - 17
[2] Hyperhomocysteinaemia, methylenetetrahydrofolate reductase polymorphism and risk of coronary artery disease
Kerkeni, M
Addad, F
Chauffert, M
Myara, A
Gerhardt, M
Chevenne, D
Trivin, F
Ben Farhat, M
Miled, A
Maaroufi, K
ANNALS OF CLINICAL BIOCHEMISTRY, 2006, 43 : 200 - 206
[3] Methylenetetrahydrofolate reductase gene polymorphism and its association with coronary artery disease
Guerzoni, Alexandre Rodrigues
Pavarino-Bertelli, Erika Cristina
de Godoy, Moacir Fernandes
Graca, Carla Renata
Biselli, Patricia Matos
Silva Souza, Doroteia Rossi
Goloni Bertollo, Eny Maria
SAO PAULO MEDICAL JOURNAL, 2007, 125 (01): : 4 - 8
[4] Methylenetetrahydrofolate reductase gene polymorphism and coronary artery disease in Taiwan Chinese
Chen, TY
Chen, JH
Tsao, CJ
HAEMATOLOGICA, 2000, 85 (04) : 445 - 446
[5] METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISM AND PREMATURE CORONARY ARTERY DISEASE
Zaghloul, Ahmed
Iorgoveanu, Corina
CHEST, 2018, 154 (04) : 98A - 98A
[6] Methylenetetrahydrofolate Reductase Polymorphism and Premature Coronary Artery Disease
Zaghloul, Ahmed
Iorgoveanu, Corina
Desai, Aakash
Balakumaran, Kathir
Chen, Kai
CUREUS JOURNAL OF MEDICAL SCIENCE, 2019, 11 (06)
[7] Methylenetetrahydrofolate reductase gene and coronary artery disease
vanBockxmeer, FM
Mamotte, CDS
Vasikaran, SD
Taylor, RR
CIRCULATION, 1997, 95 (01) : 21 - 23
[8] Methylenetetrahydrofolate reductase gene and coronary artery disease
Mager, A
Tiqva, P
CIRCULATION, 2000, 101 (16) : E172 - E172
[9] The severity of Coronary Artery Disease and Methylenetetrahydrofolate Reductase (MTHFR) Enzyme Gene Polymorphism
Ince, Fatma Demet
Atay, Aysenur
Koseoglu, Mehmet Hicri
Ellidag, Hamit Yasar
Yesil, Murat
Deveci, Erdal
INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL, 2016, 10 (04) : 172 - 178
[10] Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor for coronary artery disease
Morita, H
Taguchi, J
Kurihara, H
Kitaoka, M
Kaneda, H
Kurihara, Y
Maemura, K
Shindo, T
Minamino, T
Ohno, M
Yamaoki, K
Ogasawara, K
Aizawa, T
Suzuki, S
Yazaki, Y
CIRCULATION, 1997, 95 (08) : 2032 - 2036

← 1 2 3 4 5 →