[1] Univ Hosp Wurzburg, Comprehens Canc Ctr, Wurzburg, Germany
[2] Univ Wurzburg, Inst Clin Epidemiol & Biometry, Wurzburg, Germany
[3] Univ Hosp Wurzburg, Dept Gen Practice, Wurzburg, Germany
[4] Goethe Univ Frankfurt, Inst Gen Practice, Frankfurt, Germany
[5] Univ Duisburg Essen, Med Fac, Dept Integrat Med, Bamberg, Germany
[6] Sozialstiftung Bamberg, Dept Internal & Integrat Med, Bamberg, Germany
[7] Bavarian Hlth & Food Safety Author, State Inst Hlth 1, Erlangen, Germany
[8] Univ Hosp Wurzburg, Dept Internal Med 2, Wurzburg, Germany