Enantioselective Construction of Carbocyclic and Heterocyclic Tertiary Boronic Esters by Conjunctive Cross-Coupling Reaction

被引：6

作者：

Zhang, Xuntong ^{[1
]}

Gao, Chenpeng ^{[1
]}

Morken, James P. ^{[1
]}

机构：

[1] Boston Coll, Merkert Chem Ctr, Dept Chem, Chestnut Hill, MA 02467 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2023年 / 145卷 / 30期

关键词：

SECONDARY; ALCOHOLS;

D O I：

10.1021/jacs.3c05815

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of stereodefined carbocyclicand heterocyclic tertiaryboronic esters is accomplished by performing a conjunctive cross-couplingreaction on preformed cyclic boron ate complexes. Boronates bearingspirocyclic and aryl bicyclic skeletons can be synthesized enantioselectivelyusing a chiral PHOX-ligated Pd catalyst with achiral starting material,while substrates bearing continuous stereogenic centers can be generateddiastereoselectively. A variety of aryl and alkenyl electrophilesare incorporated.

引用

页码：16344 / 16349

页数：6

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