Serum Levels of Vitamins and Trace Elements in Patients with Visceral Leishmaniasis: a Systematic Review and Meta-analysis

被引:4
|
作者
Chaudhary, Vaibhav [1 ]
Kumari, Sweta [1 ]
Pal, Biplab [1 ]
机构
[1] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India
关键词
Vitamins; Trace elements; Minerals; Retinol; Micronutrients; Visceral leishmaniasis; RISK-FACTORS; CUTANEOUS LEISHMANIASIS; KALA-AZAR; ZINC; COPPER; IRON; INFECTION; RESPONSES; CHILDREN; IMMUNITY;
D O I
10.1007/s12011-023-04015-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Visceral leishmaniasis (VL), a fatal disease prevalent in more than 70 countries, poses significant health challenges, particularly in poor communities with limited access to healthcare. Vitamins and trace elements play a crucial role in immune function and may influence susceptibility to VL. This systematic review and meta-analysis aimed to assess the differences in serum vitamin and trace element levels in VL patients compared to healthy individuals. We conducted an extensive search of databases (PubMed, Embase, and Google Scholar) to identify potentially eligible articles published from inception to June 2023. Data extraction and quality assessment were carried out by two reviewers independently. RevMan software (version 5.4) was used for analysis. Standardized mean difference (SMD) with a confidence interval (CI) of 95% was used to summarize the findings. Ten studies comprising 546 VL patients and 535 controls were included in our study. The findings revealed significantly reduced serum retinol levels in VL patients in comparison to controls (SMD: - 0.67; 95% CI: [- 1.05, - 0.28]; p = 0.0008). Serum zinc levels were also substantially lower in VL patients, regardless of controls recruited from endemic (SMD: - 2.65; 95% CI: [- 3.86, - 1.44]; p < 0.0001) or non-endemic regions (SMD: - 1.99; 95% CI: [- 3.02, - 0.96]; p < 0.0002). However, VL patients exhibited significantly increased serum copper levels compared to controls (SMD: 2.51; 95% CI: [0.70, 4.32]; p = 0.007). Patients with VL had lower serum levels of zinc and retinol and higher levels of copper, indicating a possible role of these micronutrients in influencing VL susceptibility and progression.
引用
收藏
页码:4345 / 4356
页数:12
相关论文
共 50 条
  • [21] Serum selenium levels in tuberculosis patients: A systematic review and meta-analysis
    Muzembo, Basilua Andre
    Mbendi, Nlombi Charles
    Ngatu, Nlandu Roger
    Suzuki, Tomoko
    Wada, Koji
    Ikeda, Shunya
    JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 2018, 50 : 257 - 262
  • [22] Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis
    Wu, Ruiying
    Li, Yuanwen
    Peng, Hongye
    Yang, Zhishan
    Wang, Ying
    Lv, Shuying
    Yang, Dingquan
    JOURNAL OF COSMETIC DERMATOLOGY, 2025, 24 (01)
  • [23] Dynamic changes of serum trace elements following cardiac surgery: A systematic review and meta-analysis
    Mazaheri-Tehrani, Sadegh
    Haghighatpanah, Mohammad Ali
    Abhari, Amir Parsa
    Fakhrolmobasheri, Mohammad
    Shekarian, Arman
    Kieliszek, Marek
    JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 2024, 81
  • [24] Shining a Light on Trace Elements: A Systematic Review and Meta-analysis of Serum Concentrations in Febrile seizure
    Abbasi, Hamid
    Khoshdooz, Sara
    Abbasi, Mohammad Mehdi
    Pasand, Mohammadjavad
    Eslamian, Ghazaleh
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2025, 203 (02) : 729 - 744
  • [25] Magnitude of visceral leishmaniasis and poor treatment outcome among HIV patients: meta-analysis and systematic review
    Alemayehu, Mekuriaw
    Wubshet, Mamo
    Mesfin, Nebiyu
    HIV AIDS-RESEARCH AND PALLIATIVE CARE, 2016, 8 : 75 - 81
  • [26] Prognostic factors for mortality among patients with visceral leishmaniasis in East Africa: Systematic review and meta-analysis
    Abongomera, Charles
    van Henten, Saskia
    Vogt, Florian
    Buyze, Jozefien
    Verdonck, Kristien
    van Griensven, Johan
    PLOS NEGLECTED TROPICAL DISEASES, 2020, 14 (05): : 1 - 19
  • [27] Accuracy of the direct agglutination test for diagnosis of visceral leishmaniasis: a systematic review and meta-analysis
    Tamalee Roberts
    Suzanne H. Keddie
    Sayaphet Rattanavong
    Santiago Rayment Gomez
    John Bradley
    Ruth H. Keogh
    Oliver Bärenbold
    Jane Falconer
    Petra F. Mens
    Heidi Hopkins
    Elizabeth A. Ashley
    BMC Infectious Diseases, 23
  • [28] Serious adverse events following treatment of visceral leishmaniasis: A systematic review and meta-analysis
    Singh-Phulgenda, Sauman
    Dahal, Prabin
    Ngu, Roland
    Maguire, Brittany J.
    Hawryszkiewycz, Alice
    Rashan, Sumayyah
    Brack, Matthew
    Halleux, Christine M.
    Alves, Fabiana
    Stepniewska, Kasia
    Olliaro, Piero L.
    Guerin, Philippe J.
    PLOS NEGLECTED TROPICAL DISEASES, 2021, 15 (03):
  • [29] Accuracy of the direct agglutination test for diagnosis of visceral leishmaniasis: a systematic review and meta-analysis
    Roberts, Tamalee
    Keddie, Suzanne H.
    Rattanavong, Sayaphet
    Gomez, Santiago Rayment
    Bradley, John
    Keogh, Ruth H.
    Barenbold, Oliver
    Falconer, Jane
    Mens, Petra F.
    Hopkins, Heidi
    Ashley, Elizabeth A.
    BMC INFECTIOUS DISEASES, 2023, 23 (01)
  • [30] Serum levels of adipokines and cytokines in psoriasis patients: a systematic review and meta-analysis
    Bai, Fan
    Zheng, Wen
    Dong, Yan
    Wang, Juan
    Garstka, Malgorzata A.
    Li, Ruilian
    An, Jingang
    Ma, Huiqun
    ONCOTARGET, 2018, 9 (01) : 1266 - 1278