Comparison of resting tremor at the upper limb joints between patients with Parkinson's disease and scans without evidence of dopaminergic deficit

被引:4
|
作者
Kwon, Do-Young [1 ]
Kwon, Yu-Ri [2 ,3 ]
Ko, Junghyuk [4 ]
Kim, Ji-Won [2 ,3 ]
机构
[1] Korea Univ, Coll Med, Dept Neurol, Ansan, South Korea
[2] Konkuk Univ, Dept Biomed Engn, Chungju, South Korea
[3] Konkuk Univ, Inst Biomed Engn, Chungju, South Korea
[4] Korea Maritime & Ocean Univ, Coll Engn, Div Mech Engn, Busan, South Korea
基金
新加坡国家研究基金会;
关键词
Quantification; resting tremor; gyro sensor; SWEDD; Parkinson's disease; CLINICAL-EVALUATION; SWEDDS PATIENTS; PROGRESSION; DIAGNOSIS; ACCURACY; LEVODOPA; CIT;
D O I
10.3233/THC-236045
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
BACKGROUND: A representative symptom of Parkinson's disease (PD) is resting tremor. The clinical manifestation of scans without evidence of dopaminergic deficit (SWEDD) is similar to it of PD, though the phenomenology of SWEDD is not well known. OBJECTIVE: In the present study, the resting tremor of 9 SWEDD patients was quantitatively compared with that of 11 PD patients. METHODS: Four 3-axis gyro sensors were attached on the index finger, thumb, dorsum of the hand, and arm of the more tremulous side. Root mean square (RMS) angular speed and angular displacement as well as irregularity of angular speed and displacement were derived from the sensor data. RESULTS: Although disease duration and Hoehn and Yahr stages were comparable, SWEDD patients exhibited different tremor features from PD patients. Significantly faster RMS angular speed and greater RMS angular displacement (p < 0.05) were observed in PD patients than in SWEDD patients. The irregularity of angular displacement of pitch direction at the dorsum of the hand was greater in SWEDD patients than in PD patients ( p < 0.05). CONCLUSION: These results indicate that quantitative indices obtained from resting tremor task could be important biomarkers for identifying potential patients with SWEDD among patients diagnosed with PD.
引用
收藏
页码:S515 / S523
页数:9
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