BIOMIMETIC, PHASE-CHANGE MICROSYSTEMS FOR BREATH CONDENSATE BASED POINT-OF-CARE DIAGNOSTICS

被引：0

作者：

Morales-Cruz, Pablo ^{[1
]}

Tregansin, Maria ^{[1
]}

Fnu, Joshua ^{[1
]}

Castro, Jorge Manrique ^{[1
]}

Rajaraman, Swaminathan ^{[1
,2
]}

机构：

[1] Univ Cent Florida, Orlando, FL 32816 USA

[2] Primordia Biosyst, Costa Mesa, CA 92626 USA

来源：

2024 IEEE 37TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS | 2024年

关键词：

Biomimicry; Phase Change; Breath Condensate; Point-of-Care Microsystems; Diagnostics; Biomarkers; Virus Detection;

D O I：

10.1109/MEMS58180.2024.10439320

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Herein, we report on a novel, biomimetic [Stenocara gracilipes (Namib desert beetle)]-based microsystem, for collecting exhaled breath for use in point-of-care (POC) settings. The overall platform consists of a 50x50 mm 3D printed micro-chamber which is decorated with a PDMS micromolded Breath Condensate Collection Chip (BCCC) emulating the morphology of the beetle. The micro-chamber and BCCC are further treated with superhydrophobic coatings for enhancement in condensate collection. Breath trials were conducted to determine optimum biomimetic design, conditions for ease of use and efficient collection resulting in a maximum of similar to 82 mu L breath condensate recorded in 30s which can be further analyzed for potential biomarkers with our established wireless, microfluidic, imaging platform [1]. This microsystem exhibits the potential to be adapted to a variety of different POC assays: agglutination, colorimetric, and bead-based [2, 3, 4]. Furthermore, this diagnostic platform can be utilized to screen for a multitude of viruses/biomarkers present in exhaled breath [5].

引用

页码：457 / 460

页数：4

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