N-(4-methoxybenzyl)-L-tyrosine ethyl ester: Synthesis, structural analysis, and reaction with formaldehyde

被引：3

作者：

Chaves, Sebastian ^{[1
,2
]}

Macias, Mario ^{[3
]}

Quevedo, Rodolfo ^{[1
]}

机构：

[1] Univ Nacl Colombia, Fac Ciencias, Dept Quim, Carrera 30 45-03, Bogota, Colombia

[2] Univ ECCI, Dept Ciencias Bas, Carrera 19 49-20, Bogota, Colombia

[3] Univ los Andes, Dept Chem, Crystallog & Chem Mat, CrisQuimMat, Carrera 1 18A-10, Bogota 111711, Colombia

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2024年 / 1298卷

关键词：

Crystal structure; L-tyrosine; Mannich; Cyclophane; Macrocycle; INTERMOLECULAR INTERACTIONS; CRYSTAL-STRUCTURE; HYDROGEN-BONDS; SOLID-STATE; TYROSINE; MICROWAVE; TYRAMINE;

D O I：

10.1016/j.molstruc.2023.137079

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This paper describes the structural analysis by single crystal X-ray diffraction (SCXRD) of N-(4-methoxybenzyl)-L-tyrosine ethyl ester; a scorpion-like conformation was revealed between the ethoxycarbonyl group and the 4-hydroxyphenyl group. Zig-zag linear arrangements having head-to-tail intermolecular hydrogen bonds (O-H center dot center dot center dot N) were also observed between N-(4-methoxybenzyl)-L-tyrosine ethyl ester units. It was determined that this amine reacts with formaldehyde to form linear dimers, trimers, and tetramers made up of N-(4-methox-ybenzyl)-L-tyrosine ethyl ester units linked by methylene bridges.

引用

页数：7

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