Four undescribed iridoid glycosides with antidiabetic activity from fruits of Cornus officinalis Sieb. Et Zucc.

被引：4

作者：

Yang, Meng ^{[1
,2
]}

Hao, Zhiyou ^{[1
,2
]}

Wang, Xiaolan ^{[2
,3
]}

Zhou, Shiqi ^{[1
,2
]}

Xian, Chaoyuan ^{[1
,2
]}

Zhu, Denghui ^{[1
,2
]}

Yang, Ying ^{[1
,2
]}

Wei, Junjun ^{[1
,2
]}

Zheng, Xiaoke ^{[1
,2
]}

Feng, Weisheng ^{[1
,2
]}

机构：

[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China

[2] Engn & Technol Ctr Chinese Med Dev Henan Prov Chin, Zhengzhou 450046, Peoples R China

[3] Henan Univ Chinese Med, Acad Chinese Med Sci, Zhengzhou 450046, Peoples R China

来源：

FITOTERAPIA | 2023年 / 165卷

关键词：

Cornus officinalis Sieb; Et Zucc; Iridoid glycosides; Structure elucidation; Antidiabetic activity; FRUCTUS;

D O I：

10.1016/j.fitote.2022.105393

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four novel iridoid glycosides neocornuside E-H (1-4), together with nine known ones (5-13), were isolated from fruits of Cornus officinalis. Their chemical structures were determined on the basis of spectroscopic analyses and comparing of the literature data. All of the isolated compounds were evaluated for their antidiabetic activity in insulin resistant HepG2 cells. Compounds 2, 4, 5, 8, and 12 exhibited antidiabetic activities with EC50 values of 40.12, 2.54, 70.43, 15.31, and 4.86 mu M, respectively. Flow Sight cytometry analysis indicated that compounds 2, 4, 5, 8, and 12 improved the ability of 2-NBDG uptake of insulin-induced HepG2 cells.

引用

页数：10

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