Clinical and dermoscopic variation of basal cell carcinoma according to age of onset and anatomic location: a multicenter, retrospective study

被引:2
|
作者
Song, Zexing [1 ,2 ]
Wang, Yifei [1 ,2 ]
Meng, Rusong [3 ]
Chen, Zhenyuan [4 ]
Gao, Yaoying [1 ,2 ]
An, Xiangjie [1 ,2 ]
Yang, Jing [1 ,2 ]
Yin, Yue [1 ,2 ]
Chen, Liuqing [5 ]
Xin, Linlin [6 ,7 ]
Xia, Ying [8 ]
Tao, Juan [1 ,2 ]
Yang, Liu [1 ,2 ]
机构
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Dermatol, 1277 Jiefang Ave, Wuhan 430022, Hubei, Peoples R China
[2] Hubei Engn Res Ctr Skin Dis Theranost & Hlth, Wuhan 430022, Hubei, Peoples R China
[3] Chinese Peoples Liberat Army, Specialty Med Ctr Air Force, Dept Dermatol, Beijing 100142, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Social Med & Hlth Management, Wuhan 430030, Hubei, Peoples R China
[5] Wuhan No 1 Hosp, Dept Dermatol, Wuhan 430030, Hubei, Peoples R China
[6] Shandong First Med Univ, Affiliated Hosp 1, Dept Dermatol, Jinan 250014, Shandong, Peoples R China
[7] Shandong Prov Qianfoshan Hosp, Jinan 250014, Shandong, Peoples R China
[8] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Dermatol, Wuhan 430030, Hubei, Peoples R China
基金
中国国家自然科学基金;
关键词
Basal cell carcinoma; Age; Anatomic location; Dermoscopy; Morphology; VASCULAR PATTERNS; RISK-FACTORS; MICROSCOPY;
D O I
10.1007/s00403-023-02556-y
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Basal cell carcinoma (BCC) is rare in young individuals and reported to possess different pathogenetic, clinical and histological features from late-onset BCC. However, the dermoscopic variability of BCC according to age of onset has not been investigated. Anatomic location was revealed to be associated with dermoscopic variation of BCC in Western population, but whether it applies to Asian population remains unknown. We evaluated the clinical and dermoscopic features of 448 BCCs and compared each feature by age of onset (age < 50/ > 50 years) and anatomic location. Early-onset BCCs occurred more frequently on non-sun-exposed sites (OR 3.28, P = 0.001) and were less pigmented than late-onset BCCs (P = 0.003). Blue-gray globules (OR 1.74, P = 0.037) and no vessels (OR 2.04, P = 0.021) were independently associated with early-onset BCCs, whereas arborizing telangiectasia (OR 0.30, P < 0.001), large blue-gray ovoid nests (OR 0.38, P < 0.001) and ulceration (OR 0.33, P < 0.001) were less common in early-onset BCCs. Scalp BCCs were significantly more pigmented than BCCs located elsewhere (P = 0.022). Superficial subtype (OR 5.90, P < 0.001), spoke-wheel areas (OR 4.78, P = 0.034), superficial erosions (OR 4.69, P = 0.003) and polymorph vessels (OR 6.86, P = 0.001) were independently associated with trunk BCCs, whereas nodular subtype (OR 5.48, P < 0.001) and arborizing telangiectasias (OR 3.64, P < 0.001) with BCCs on face and neck. Our findings suggest that age of onset and anatomic location are independent factors affecting the dermoscopic appearance of BCC.
引用
收藏
页码:1655 / 1664
页数:10
相关论文
共 50 条
  • [41] A Multicenter, Retrospective Comparison Study of Pregnancy Outcomes According to Placental Location in Placenta Previa
    Lee, Seon Ui
    Jo, Ji Hye
    Lee, Haein
    Na, Yoojin
    Park, In Yang
    JOURNAL OF CLINICAL MEDICINE, 2024, 13 (03)
  • [42] Clinical and dermoscopic features of atypical Spitz tumors: A multicenter, retrospective, case-control study
    Moscarella, Elvira
    Lallas, Aimilios
    Kyrgidis, Athanassios
    Ferrara, Gerardo
    Longo, Caterina
    Scalvenzi, Massimiliano
    Staibano, Stefania
    Carrera, Cristina
    Alba Diaz, M.
    Broganelli, Paolo
    Tomasini, Carlo
    Cavicchini, Stefano
    Gianotti, Raffaele
    Puig, Susana
    Malvehy, Josep
    Zaballos, Pedro
    Pellacani, Giovanni
    Argenziano, Giuseppe
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2015, 73 (05) : 777 - 784
  • [43] Epidemiological and clinicopathological analysis of basal cell carcinoma in Egyptian population: a 5-year retrospective multicenter study
    El-Khalawany, Mohamed
    Hassab-El-Naby, Hussein M. M.
    Mousa, Ahmed Mustafa
    Sameh, Ahmed
    Rageh, Mahmoud A.
    Genedy, Rasha Mahmoud
    Hosny, Aya Magdy
    Aboelmagd, Marwa A.
    Aboeldahab, Soha
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023, 149 (07) : 3121 - 3129
  • [44] Epidemiological and clinicopathological analysis of basal cell carcinoma in Egyptian population: a 5-year retrospective multicenter study
    Mohamed El-Khalawany
    Hussein M. M. Hassab-El-Naby
    Ahmed Mustafa Mousa
    Ahmed Sameh
    Mahmoud A. Rageh
    Rasha Mahmoud Genedy
    Aya Magdy Hosny
    Marwa A. Aboelmagd
    Soha Aboeldahab
    Journal of Cancer Research and Clinical Oncology, 2023, 149 : 3121 - 3129
  • [45] A Retrospective clinical review of Periocular Basal Cell carcinoma outcomes in Glasgow: A 5 year study
    Williams, Olayinka Ann-marie
    Erikitola, Ore-oluwa Catherine
    Diaper, Charles
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2019, 60 (09)
  • [46] Facial basal cell carcinoma: A retrospective study of 67 cases
    Khalil, Afrah A.
    Enezei, Hamid H.
    Aldelaimi, Tahrir N.
    Al-Ani, Raid M.
    WORLD JOURNAL OF CLINICAL CASES, 2023, 11 (07) : 1488 - 1497
  • [47] Vulvar basal cell carcinoma: retrospective study and review of literature
    de Giorgi, V
    Salvini, C
    Massi, D
    Raspollini, MR
    Carli, P
    GYNECOLOGIC ONCOLOGY, 2005, 97 (01) : 192 - 194
  • [48] Facial basal cell carcinoma: A retrospective study of 67 cases
    Afrah A Khalil
    Hamid H Enezei
    Tahrir N Aldelaimi
    Raid M Al-Ani
    World Journal of Clinical Cases, 2023, (07) : 1488 - 1497
  • [49] Topography of basal cell carcinoma and their correlations with gender, age and histologic pattern: a retrospective study of 1042 lesions
    Dias Souza, Claudia Fernanda
    Thome, Emanuela Plech
    Menegotto, Paula Fatuch
    Schmitt, Juliano Vilaverde
    Toshio Shibue, Jose Roberto
    Tarle, Roberto Gomes
    ANAIS BRASILEIROS DE DERMATOLOGIA, 2011, 86 (02) : 272 - 277
  • [50] A 5-year retrospective cohort study of basal cell carcinomas on the head and neck: Anatomic location as a predictor of subclinical tumour extension
    Tan, Marcus G.
    Yu, Ashley M.
    Macdonald, Jillian
    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2023, 37 (01) : E101 - E103