Clinical and dermoscopic variation of basal cell carcinoma according to age of onset and anatomic location: a multicenter, retrospective study

被引:2
|
作者
Song, Zexing [1 ,2 ]
Wang, Yifei [1 ,2 ]
Meng, Rusong [3 ]
Chen, Zhenyuan [4 ]
Gao, Yaoying [1 ,2 ]
An, Xiangjie [1 ,2 ]
Yang, Jing [1 ,2 ]
Yin, Yue [1 ,2 ]
Chen, Liuqing [5 ]
Xin, Linlin [6 ,7 ]
Xia, Ying [8 ]
Tao, Juan [1 ,2 ]
Yang, Liu [1 ,2 ]
机构
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Dermatol, 1277 Jiefang Ave, Wuhan 430022, Hubei, Peoples R China
[2] Hubei Engn Res Ctr Skin Dis Theranost & Hlth, Wuhan 430022, Hubei, Peoples R China
[3] Chinese Peoples Liberat Army, Specialty Med Ctr Air Force, Dept Dermatol, Beijing 100142, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Social Med & Hlth Management, Wuhan 430030, Hubei, Peoples R China
[5] Wuhan No 1 Hosp, Dept Dermatol, Wuhan 430030, Hubei, Peoples R China
[6] Shandong First Med Univ, Affiliated Hosp 1, Dept Dermatol, Jinan 250014, Shandong, Peoples R China
[7] Shandong Prov Qianfoshan Hosp, Jinan 250014, Shandong, Peoples R China
[8] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Dermatol, Wuhan 430030, Hubei, Peoples R China
基金
中国国家自然科学基金;
关键词
Basal cell carcinoma; Age; Anatomic location; Dermoscopy; Morphology; VASCULAR PATTERNS; RISK-FACTORS; MICROSCOPY;
D O I
10.1007/s00403-023-02556-y
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Basal cell carcinoma (BCC) is rare in young individuals and reported to possess different pathogenetic, clinical and histological features from late-onset BCC. However, the dermoscopic variability of BCC according to age of onset has not been investigated. Anatomic location was revealed to be associated with dermoscopic variation of BCC in Western population, but whether it applies to Asian population remains unknown. We evaluated the clinical and dermoscopic features of 448 BCCs and compared each feature by age of onset (age < 50/ > 50 years) and anatomic location. Early-onset BCCs occurred more frequently on non-sun-exposed sites (OR 3.28, P = 0.001) and were less pigmented than late-onset BCCs (P = 0.003). Blue-gray globules (OR 1.74, P = 0.037) and no vessels (OR 2.04, P = 0.021) were independently associated with early-onset BCCs, whereas arborizing telangiectasia (OR 0.30, P < 0.001), large blue-gray ovoid nests (OR 0.38, P < 0.001) and ulceration (OR 0.33, P < 0.001) were less common in early-onset BCCs. Scalp BCCs were significantly more pigmented than BCCs located elsewhere (P = 0.022). Superficial subtype (OR 5.90, P < 0.001), spoke-wheel areas (OR 4.78, P = 0.034), superficial erosions (OR 4.69, P = 0.003) and polymorph vessels (OR 6.86, P = 0.001) were independently associated with trunk BCCs, whereas nodular subtype (OR 5.48, P < 0.001) and arborizing telangiectasias (OR 3.64, P < 0.001) with BCCs on face and neck. Our findings suggest that age of onset and anatomic location are independent factors affecting the dermoscopic appearance of BCC.
引用
收藏
页码:1655 / 1664
页数:10
相关论文
共 50 条
  • [1] Clinical and dermoscopic variation of basal cell carcinoma according to age of onset and anatomic location: a multicenter, retrospective study
    Zexing Song
    Yifei Wang
    Rusong Meng
    Zhenyuan Chen
    Yaoying Gao
    Xiangjie An
    Jing Yang
    Yue Yin
    Liuqing Chen
    Linlin Xin
    Ying Xia
    Juan Tao
    Liu Yang
    Archives of Dermatological Research, 2023, 315 : 1655 - 1664
  • [2] Dermoscopic variability of basal cell carcinoma according to clinical type and anatomic location
    Suppa, M.
    Micantonio, T.
    Di Stefani, A.
    Soyer, H. P.
    Chimenti, S.
    Fargnoli, M. C.
    Peris, K.
    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2015, 29 (09) : 1732 - 1741
  • [3] Basal cell carcinoma: differences according to anatomic location and clinical-pathological subtypes
    Pranteda, G.
    Grimaldi, M.
    Lombardi, M.
    Pranteda, G.
    Arcese, A.
    Cortesi, G.
    Muscianese, M.
    Bottoni, U.
    GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA, 2014, 149 (04): : 423 - 426
  • [4] Variation in dermoscopic features of basal cell carcinoma as a function of anatomical location and pigmentation status
    Wolner, Z. J.
    Bajaj, S.
    Flores, E.
    Carrera, C.
    Navarrete-Dechent, C.
    Dusza, S. W.
    Rabinovitz, H. S.
    Marchetti, M. A.
    Marghoob, A. A.
    BRITISH JOURNAL OF DERMATOLOGY, 2018, 178 (02) : E136 - E137
  • [5] Dermoscopy of Basal Cell Carcinoma Part 2: Dermoscopic Findings by Lesion Subtype, Location, Age of Onset, Size and Patient Phototype
    Wojtowicz, Irena
    Zychowska, Magdalena
    CANCERS, 2025, 17 (02)
  • [6] Dermoscopic features of pigmented basal cell carcinoma according to size
    Wang, Wei-En
    Chen, Yen-Ting
    Wang, Chien-Hsing
    Wang, Jen-Hung
    Chang, Chung-Hsing
    INTERNATIONAL JOURNAL OF DERMATOLOGY, 2024, 63 (07) : 916 - 921
  • [7] Dermoscopic Ulceration is a Predictor of Basal Cell Carcinoma Response to Imiquimod: A Retrospective Study
    Urech, Marta
    Kyrgidis, Athanassios
    Argenziano, Giuseppe
    Reggiani, Camilla
    Moscarella, Elvira
    Longo, Caterina
    Alfano, Roberto
    Zalaudek, Iris
    Lallas, Aimilios
    ACTA DERMATO-VENEREOLOGICA, 2017, 97 (01) : 117 - 119
  • [8] Clinical, Dermoscopic and Histopathological Evaluation of Basal Cell Carcinoma
    Urun, Yildiz Gursel
    Ficicioglu, Sezin
    Urun, Mustafa
    Can, Nuray
    DERMATOLOGY PRACTICAL & CONCEPTUAL, 2023, 13 (01):
  • [9] Proposal of a new dermoscopic criterion for pigmented basal cell carcinoma: a multicentre retrospective study
    Manca, Roberto
    Dattolo, Anna
    Valenzano, Francesco
    Castriota, Marina
    Martella, Alessandro
    Galdo, Giovanna
    Argenziano, Giuseppe
    Abeni, Damiano
    Fania, Luca
    DERMATOLOGY REPORTS, 2024, 16 (01)
  • [10] Dermoscopic features of face and scalp basal and squamous cell carcinomas according to clinical histopathologic characteristics and anatomical location
    Fagotti, S.
    Pizzichetta, M. A.
    Corneli, P.
    Toffolutti, F.
    Serraino, D.
    di Meo, N.
    Zalaudek, I.
    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2021, 35 (03) : E237 - E239