Neuropsychological Evaluation and Quantitative EEG in Patients with Frontotemporal Dementia, Alzheimer's Disease, and Mild Cognitive Impairment

被引:1
|
作者
Tomasello, Letteria [1 ,2 ]
Carlucci, Leonardo [3 ]
Lagana, Angelina [4 ]
Galletta, Santi [5 ]
Marinelli, Chiara Valeria [3 ]
Raffaele, Massimo [1 ]
Zoccolotti, Pierluigi [6 ,7 ]
机构
[1] Univ Messina, Dept Clin & Expt Med, I-98122 Messina, Italy
[2] Sapienza Univ Rome, Fac Med & Dent, I-00185 Rome, Italy
[3] Foggia Univ, Dept Humanities Letters Cultural Heritage & Educ, Learning Sci Hub, I-71121 Foggia, Italy
[4] Dept Biomed & Dent Sci Morphol & Funct Images, I-98122 Messina, Italy
[5] Reseau Hosp Neuchatelois RHNe, Serv Neurol & Neuroreadaptat, CH-2000 Neuchatel, Switzerland
[6] Tuscany Rehabil Clin, I-52025 Montevarchi, Italy
[7] Sapienza Univ Rome, Dept Psychol, I-00185 Rome, Italy
关键词
dementia; Alzheimer's; MCI; EEG; neuropsychological profile; MENTAL-STATE-EXAMINATION; ELECTROENCEPHALOGRAPHY; POWER; DETERIORATION; PREVALENCE; MECHANISMS; COHERENCE; DIAGNOSIS; PEOPLE; BRAIN;
D O I
10.3390/brainsci13060930
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This study analyzed the efficacy of EEG resting state and neuropsychological performances in discriminating patients with different forms of dementia, or mild cognitive impairment (MCI), compared with control subjects. Forty-four patients with dementia (nineteen patients with AD, and seven with FTD), eighteen with MCI, and nineteen healthy subjects, matched for age and gender, underwent an extensive neuropsychological test battery and an EEG resting state recording. Results showed greater theta activation in posterior areas in the Alzheimer's disease (AD) and Fronto-Temporal Dementia (FTD) groups compared with the MCI and control groups. AD patients also showed more delta band activity in the temporal-occipital areas than controls and MCI patients. By contrast, the alpha and beta bands did not discriminate among groups. A hierarchical clustering analysis based on neuropsychological and EEG data yielded a three-factor solution. The clusters differed for several neuropsychological measures, as well as for beta and theta bands. Neuropsychological tests were most sensitive in capturing an initial cognitive decline, while increased theta activity was uniquely associated with a substantial worsening of the clinical picture, representing a negative prognostic factor. In line with the Research Domains Framework (RDoC) perspective, the joint use of cognitive and neurophysiological data may provide converging evidence to document the evolution of cognitive skills in at-risk individuals.
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页数:16
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